Thermostability and polymorphism of theobroma oil and palm kernel oil as suppository bases
Thermal stability of pharmaceutical ingredients is an important aspect. In this study, we adopted differential scanning calorimetry (DSC) to investigate thermal stability of suppository bases, theobroma oil (cocoa butter) and a palm kernel oil (PKO) blend. The study shows theobroma oil possesses six...
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| Format: | Article |
| Language: | English |
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2009
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| Online Access: | http://eprints.um.edu.my/8158/1/Noordin-2009-THERMOSTABILITY_AND.pdf |
| _version_ | 1825719494535806976 |
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| author | Noordin, M.I. Chung, L.Y. |
| author_facet | Noordin, M.I. Chung, L.Y. |
| author_sort | Noordin, M.I. |
| collection | UM |
| description | Thermal stability of pharmaceutical ingredients is an important aspect. In this study, we adopted differential scanning calorimetry (DSC) to investigate thermal stability of suppository bases, theobroma oil (cocoa butter) and a palm kernel oil (PKO) blend. The study shows theobroma oil possesses six polymorphic forms whilst the palm kernel oil blend has three. Upon rescanning, the PKO blend does not show changes in the enthalpy of fusion and the melting point with time, whilst the theobroma oil shows significant reduction, and only regained its thermal stable state after 10 days. This indicates that PKO blend possesses better thermal stability. |
| first_indexed | 2024-03-06T05:20:36Z |
| format | Article |
| id | um.eprints-8158 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:20:36Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | um.eprints-81582013-07-22T02:26:52Z http://eprints.um.edu.my/8158/ Thermostability and polymorphism of theobroma oil and palm kernel oil as suppository bases Noordin, M.I. Chung, L.Y. R Medicine Thermal stability of pharmaceutical ingredients is an important aspect. In this study, we adopted differential scanning calorimetry (DSC) to investigate thermal stability of suppository bases, theobroma oil (cocoa butter) and a palm kernel oil (PKO) blend. The study shows theobroma oil possesses six polymorphic forms whilst the palm kernel oil blend has three. Upon rescanning, the PKO blend does not show changes in the enthalpy of fusion and the melting point with time, whilst the theobroma oil shows significant reduction, and only regained its thermal stable state after 10 days. This indicates that PKO blend possesses better thermal stability. 2009 Article PeerReviewed application/pdf en http://eprints.um.edu.my/8158/1/Noordin-2009-THERMOSTABILITY_AND.pdf Noordin, M.I. and Chung, L.Y. (2009) Thermostability and polymorphism of theobroma oil and palm kernel oil as suppository bases. Journal of Thermal Analysis and Calorimetry, 95 (3). pp. 891-894. ISSN 1388-6150, DOI https://doi.org/10.1007/s10973-008-9152-6 <https://doi.org/10.1007/s10973-008-9152-6>. http://link.springer.com/content/pdf/10.1007%2Fs10973-008-9152-6.pdf 10.1007/s10973-008-9152-6 |
| spellingShingle | R Medicine Noordin, M.I. Chung, L.Y. Thermostability and polymorphism of theobroma oil and palm kernel oil as suppository bases |
| title | Thermostability and polymorphism of theobroma oil and palm kernel oil as suppository bases |
| title_full | Thermostability and polymorphism of theobroma oil and palm kernel oil as suppository bases |
| title_fullStr | Thermostability and polymorphism of theobroma oil and palm kernel oil as suppository bases |
| title_full_unstemmed | Thermostability and polymorphism of theobroma oil and palm kernel oil as suppository bases |
| title_short | Thermostability and polymorphism of theobroma oil and palm kernel oil as suppository bases |
| title_sort | thermostability and polymorphism of theobroma oil and palm kernel oil as suppository bases |
| topic | R Medicine |
| url | http://eprints.um.edu.my/8158/1/Noordin-2009-THERMOSTABILITY_AND.pdf |
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