Impairment of IgG Fc functions promotes tumor progression and suppresses NK cell antitumor actions

Impairment of IgG Fc functions promotes tumor progression and suppresses NK cell antitumor actions

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Natural killer (NK) cells mediate antibody dependent cytotoxic killing of cancer cells via cross-linking FcγR on NK cells with IgG-Fc. Studies have shown that the single-hinge cleaved IgGs (scIgGs) have dysfunctional Fc and failed engagement with FcγRs on immune cells. However, little is known about...

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Bibliographic Details
Main Authors: Xuejun Fan, Zihao Yuan, Yueshui Zhao, Wei Xiong, Hsiao, Hao-Ching, Rahmawati Pare, Jianmin Ding, Ahmad Almosa, Kai Sun, Songlin Zhang, Jordan, Robert E., Cheok, Song Lee, Zhiqiang An, Ningyan Zhang
Format: Article
Language:English
English
Published: Springer Nature 2022
Subjects:
RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens
Online Access:https://eprints.ums.edu.my/id/eprint/34647/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/34647/1/ABSTRACT.pdf

Internet

https://eprints.ums.edu.my/id/eprint/34647/2/FULL%20TEXT.pdf
https://eprints.ums.edu.my/id/eprint/34647/1/ABSTRACT.pdf

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