Germinated brown rice extract reduces brain lipid peroxidation and Aβ levels via regulations of BACE1, RAGE, IDE and LRP1 expressions in high fat/cholesterol diet-fed rats
A strong association presents between excessive amyloid-β (Aβ) buildup and oxidative stress with Alzheimer’s disease (AD). In view of the multifaceted neuroprotective effects of some dietary elements, the beneficial effect of germinated brown rice was investigated using a high fat/cholesterol diet (...
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| Format: | Article |
| Language: | English English |
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Elsevier
2023
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| Online Access: | https://eprints.ums.edu.my/id/eprint/38408/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/38408/2/FULL%20TEXT.pdf |
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| author | Nur Hanisah Azmi Norsharina Ismail Mustapha Umar Imam Der Jiun Ooi Zhang Yida Ahmad Hazim Abdul Aziz Mohamad Norisham Mohamad Rosdi |
| author_facet | Nur Hanisah Azmi Norsharina Ismail Mustapha Umar Imam Der Jiun Ooi Zhang Yida Ahmad Hazim Abdul Aziz Mohamad Norisham Mohamad Rosdi |
| author_sort | Nur Hanisah Azmi |
| collection | UMS |
| description | A strong association presents between excessive amyloid-β (Aβ) buildup and oxidative stress with Alzheimer’s disease (AD). In view of the multifaceted neuroprotective effects of some dietary elements, the beneficial effect of germinated brown rice was investigated using a high fat/cholesterol diet (HFCD)-induced sporadic rat model of AD. Seven groups, including normal control, HFCD, and HFCD treated with Donepezil, Simvastatin, Probucol, and germinated brown rice ethyl acetate extract (GBR-EA; 100 and 200 mg/kg bw) were included in the present study. Biochemical assays, brain lipid peroxidation, mRNA and protein levels involved in Aβ processing and metabolism pathways were analyzed. HFCD-fed rats exhibited increased brain lipid peroxidation and Aβ levels, as well as altered expressions of proteins involved in Aβ generation, degradation and clearance. GBR-EA treatment groups showed significant reduction in lipid peroxidation and Aβ levels when compared to HFCD group. The effects of GBR-EA on Aβ levels are likely through the modulation of BACE1 and Presenilins, as well as induction of Aβ clearance and degradation. The findings revealed the potential use of germinated brown rice to attenuate HFCD diet-induced neurodegenerative alterations, likely due to reduced brain inflammation, as well as modulation of Aβ processing and metabolism pathways. |
| first_indexed | 2024-03-06T03:28:12Z |
| format | Article |
| id | ums.eprints-38408 |
| institution | Universiti Malaysia Sabah |
| language | English English |
| last_indexed | 2024-03-06T03:28:12Z |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | ums.eprints-384082024-02-29T02:30:49Z https://eprints.ums.edu.my/id/eprint/38408/ Germinated brown rice extract reduces brain lipid peroxidation and Aβ levels via regulations of BACE1, RAGE, IDE and LRP1 expressions in high fat/cholesterol diet-fed rats Nur Hanisah Azmi Norsharina Ismail Mustapha Umar Imam Der Jiun Ooi Zhang Yida Ahmad Hazim Abdul Aziz Mohamad Norisham Mohamad Rosdi RC512-528 Psychoses RM214-258 Diet therapy. Dietary cookbooks A strong association presents between excessive amyloid-β (Aβ) buildup and oxidative stress with Alzheimer’s disease (AD). In view of the multifaceted neuroprotective effects of some dietary elements, the beneficial effect of germinated brown rice was investigated using a high fat/cholesterol diet (HFCD)-induced sporadic rat model of AD. Seven groups, including normal control, HFCD, and HFCD treated with Donepezil, Simvastatin, Probucol, and germinated brown rice ethyl acetate extract (GBR-EA; 100 and 200 mg/kg bw) were included in the present study. Biochemical assays, brain lipid peroxidation, mRNA and protein levels involved in Aβ processing and metabolism pathways were analyzed. HFCD-fed rats exhibited increased brain lipid peroxidation and Aβ levels, as well as altered expressions of proteins involved in Aβ generation, degradation and clearance. GBR-EA treatment groups showed significant reduction in lipid peroxidation and Aβ levels when compared to HFCD group. The effects of GBR-EA on Aβ levels are likely through the modulation of BACE1 and Presenilins, as well as induction of Aβ clearance and degradation. The findings revealed the potential use of germinated brown rice to attenuate HFCD diet-induced neurodegenerative alterations, likely due to reduced brain inflammation, as well as modulation of Aβ processing and metabolism pathways. Elsevier 2023 Article NonPeerReviewed text en https://eprints.ums.edu.my/id/eprint/38408/1/ABSTRACT.pdf text en https://eprints.ums.edu.my/id/eprint/38408/2/FULL%20TEXT.pdf Nur Hanisah Azmi and Norsharina Ismail and Mustapha Umar Imam and Der Jiun Ooi and Zhang Yida and Ahmad Hazim Abdul Aziz and Mohamad Norisham Mohamad Rosdi (2023) Germinated brown rice extract reduces brain lipid peroxidation and Aβ levels via regulations of BACE1, RAGE, IDE and LRP1 expressions in high fat/cholesterol diet-fed rats. Journal of Functional Foods, 105. pp. 1-12. ISSN 1756-4646 https://doi.org/10.1016/j.jff.2023.105587 |
| spellingShingle | RC512-528 Psychoses RM214-258 Diet therapy. Dietary cookbooks Nur Hanisah Azmi Norsharina Ismail Mustapha Umar Imam Der Jiun Ooi Zhang Yida Ahmad Hazim Abdul Aziz Mohamad Norisham Mohamad Rosdi Germinated brown rice extract reduces brain lipid peroxidation and Aβ levels via regulations of BACE1, RAGE, IDE and LRP1 expressions in high fat/cholesterol diet-fed rats |
| title | Germinated brown rice extract reduces brain lipid peroxidation and Aβ levels via regulations of BACE1, RAGE, IDE and LRP1 expressions in high fat/cholesterol diet-fed rats |
| title_full | Germinated brown rice extract reduces brain lipid peroxidation and Aβ levels via regulations of BACE1, RAGE, IDE and LRP1 expressions in high fat/cholesterol diet-fed rats |
| title_fullStr | Germinated brown rice extract reduces brain lipid peroxidation and Aβ levels via regulations of BACE1, RAGE, IDE and LRP1 expressions in high fat/cholesterol diet-fed rats |
| title_full_unstemmed | Germinated brown rice extract reduces brain lipid peroxidation and Aβ levels via regulations of BACE1, RAGE, IDE and LRP1 expressions in high fat/cholesterol diet-fed rats |
| title_short | Germinated brown rice extract reduces brain lipid peroxidation and Aβ levels via regulations of BACE1, RAGE, IDE and LRP1 expressions in high fat/cholesterol diet-fed rats |
| title_sort | germinated brown rice extract reduces brain lipid peroxidation and aβ levels via regulations of bace1 rage ide and lrp1 expressions in high fat cholesterol diet fed rats |
| topic | RC512-528 Psychoses RM214-258 Diet therapy. Dietary cookbooks |
| url | https://eprints.ums.edu.my/id/eprint/38408/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/38408/2/FULL%20TEXT.pdf |
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