Kinetics and mechanism of the alkaline hydrolysis of securinine

The hydroxide ion‐catalyzed hydrolysis of securinine involves the ring opening of the lactone moiety. The rate of hydrolysis is insensitive to the ionic strength. The observed pseudo‐first‐order rate constants reveal a decrease of approximately 4‐fold due to the increase in the MeCN content from 4 t...

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Bibliographic Details
Main Authors: Lajis, Nordin H., Khan, Mohammad Niyaz, M. Noor, Hamdan
Format: Article
Published: 1995