Andrographolide as a template in the synthesis of new anticancer agents with potentially novel molecular targets
Using andrographolide (AGP) as a template, a series of semisynthetic analogues was synthesised for the discovery of new anticancer agent(s) with improved antitumour selectivity and potency. SRJ09, a lead compound displayed remarkable activity in the National Cancer Institute (NCI) of USA in vitro an...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Federation of American Societies for Experimental Biology
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/13108/1/Andrographolide%20as%20a%20template%20in%20the%20synthesis%20of%20new%20anticancer%20agents%20with%20potentially%20novel%20molecular%20targets.pdf |