Pellitorine, a potential anti-cancer lead compound against HL60 and MCT-7 cell lines and microbial transformation of piperine from Piper nigrum.
Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Pi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
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MDPI
2010
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| Online Access: | http://psasir.upm.edu.my/id/eprint/16064/1/Pellitorine.pdf |
| _version_ | 1825945743326707712 |
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| author | Ee , Gwendoline Cheng Lian Lim, Chyi Meei Rahmani, Mawardi Shaari, Khozirah Bong, Choon Fah Joseph |
| author_facet | Ee , Gwendoline Cheng Lian Lim, Chyi Meei Rahmani, Mawardi Shaari, Khozirah Bong, Choon Fah Joseph |
| author_sort | Ee , Gwendoline Cheng Lian |
| collection | UPM |
| description | Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3’,4’-
(methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques. |
| first_indexed | 2024-03-06T07:36:12Z |
| format | Article |
| id | upm.eprints-16064 |
| institution | Universiti Putra Malaysia |
| language | English English |
| last_indexed | 2024-03-06T07:36:12Z |
| publishDate | 2010 |
| publisher | MDPI |
| record_format | dspace |
| spelling | upm.eprints-160642015-09-10T06:54:16Z http://psasir.upm.edu.my/id/eprint/16064/ Pellitorine, a potential anti-cancer lead compound against HL60 and MCT-7 cell lines and microbial transformation of piperine from Piper nigrum. Ee , Gwendoline Cheng Lian Lim, Chyi Meei Rahmani, Mawardi Shaari, Khozirah Bong, Choon Fah Joseph Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3’,4’- (methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques. MDPI 2010 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/16064/1/Pellitorine.pdf Ee , Gwendoline Cheng Lian and Lim, Chyi Meei and Rahmani, Mawardi and Shaari, Khozirah and Bong, Choon Fah Joseph (2010) Pellitorine, a potential anti-cancer lead compound against HL60 and MCT-7 cell lines and microbial transformation of piperine from Piper nigrum. Molecules, 15 (4). pp. 2398-2404. ISSN 1420-3049 10.3390/molecules15042398 English |
| spellingShingle | Ee , Gwendoline Cheng Lian Lim, Chyi Meei Rahmani, Mawardi Shaari, Khozirah Bong, Choon Fah Joseph Pellitorine, a potential anti-cancer lead compound against HL60 and MCT-7 cell lines and microbial transformation of piperine from Piper nigrum. |
| title | Pellitorine, a potential anti-cancer lead compound against
HL60 and MCT-7 cell lines and microbial transformation of piperine from Piper nigrum. |
| title_full | Pellitorine, a potential anti-cancer lead compound against
HL60 and MCT-7 cell lines and microbial transformation of piperine from Piper nigrum. |
| title_fullStr | Pellitorine, a potential anti-cancer lead compound against
HL60 and MCT-7 cell lines and microbial transformation of piperine from Piper nigrum. |
| title_full_unstemmed | Pellitorine, a potential anti-cancer lead compound against
HL60 and MCT-7 cell lines and microbial transformation of piperine from Piper nigrum. |
| title_short | Pellitorine, a potential anti-cancer lead compound against
HL60 and MCT-7 cell lines and microbial transformation of piperine from Piper nigrum. |
| title_sort | pellitorine a potential anti cancer lead compound against hl60 and mct 7 cell lines and microbial transformation of piperine from piper nigrum |
| url | http://psasir.upm.edu.my/id/eprint/16064/1/Pellitorine.pdf |
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