Protective effect of polyphenol-rich extract prepared from Malaysian cocoa (Theobroma cacao) on glucose levels and lipid profiles in streptozotocin-induced diabetic rats
BACKGROUND: Cocoa beans are used for preparing cocoa liquor and cocoa powder, which are the main ingredients of cocoa-based products. Previous studies have reported the health benefits of cocoa polyphenols in reducing the risk of cardiovascular diseases. However, there is no report on the efficacy...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Society of Chemical Industry
2008
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| Online Access: | http://psasir.upm.edu.my/id/eprint/16379/1/Protective%20effect%20of%20polyphenol.pdf |
| _version_ | 1796969043471630336 |
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| author | Mohd Mokhtar, Ruzaidi Azli Mhd Jalil, Abbe Maleyki Ismail, Amin Abdul Ghani, Nawalyah Hamid, Muhajir |
| author_facet | Mohd Mokhtar, Ruzaidi Azli Mhd Jalil, Abbe Maleyki Ismail, Amin Abdul Ghani, Nawalyah Hamid, Muhajir |
| author_sort | Mohd Mokhtar, Ruzaidi Azli |
| collection | UPM |
| description | BACKGROUND:
Cocoa beans are used for preparing cocoa liquor and cocoa powder, which are the main ingredients of cocoa-based products. Previous studies have reported the health benefits of cocoa polyphenols in reducing the risk of cardiovascular diseases. However, there is no report on the efficacy of cocoa polyphenols on diabetes mellitus. Therefore this study was designed to evaluate the protective effect of cocoa polyphenol-rich extract (CE) on glucose levels and lipid profiles in streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley rats were divided into diabetic control, diabetic CE and diabetic glibenclamide groups.
RESULTS:
Three different dosages of CE (10, 20 and 30 mg per 100 g body weight) were administered orally once a day for 1 week before STZ injection and for 3 weeks thereafter. The results showed that CE could normalise the body weight loss caused by STZ. In the 20 mg CE-pretreated group there was a 143% increase in plasma glucose levels, compared with a 226% increase in diabetic control rats. CE could also normalise total cholesterol, triglycerides and high-density lipoprotein cholesterol at the end of the experiment compared with the baseline.
CONCLUSION:
The present study suggests that pretreatment with CE from roasted cocoa beans could prevent the development of diabetes induced by STZ injection in rats. |
| first_indexed | 2024-03-06T07:37:15Z |
| format | Article |
| id | upm.eprints-16379 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T07:37:15Z |
| publishDate | 2008 |
| publisher | Society of Chemical Industry |
| record_format | dspace |
| spelling | upm.eprints-163792017-05-08T02:15:22Z http://psasir.upm.edu.my/id/eprint/16379/ Protective effect of polyphenol-rich extract prepared from Malaysian cocoa (Theobroma cacao) on glucose levels and lipid profiles in streptozotocin-induced diabetic rats Mohd Mokhtar, Ruzaidi Azli Mhd Jalil, Abbe Maleyki Ismail, Amin Abdul Ghani, Nawalyah Hamid, Muhajir BACKGROUND: Cocoa beans are used for preparing cocoa liquor and cocoa powder, which are the main ingredients of cocoa-based products. Previous studies have reported the health benefits of cocoa polyphenols in reducing the risk of cardiovascular diseases. However, there is no report on the efficacy of cocoa polyphenols on diabetes mellitus. Therefore this study was designed to evaluate the protective effect of cocoa polyphenol-rich extract (CE) on glucose levels and lipid profiles in streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley rats were divided into diabetic control, diabetic CE and diabetic glibenclamide groups. RESULTS: Three different dosages of CE (10, 20 and 30 mg per 100 g body weight) were administered orally once a day for 1 week before STZ injection and for 3 weeks thereafter. The results showed that CE could normalise the body weight loss caused by STZ. In the 20 mg CE-pretreated group there was a 143% increase in plasma glucose levels, compared with a 226% increase in diabetic control rats. CE could also normalise total cholesterol, triglycerides and high-density lipoprotein cholesterol at the end of the experiment compared with the baseline. CONCLUSION: The present study suggests that pretreatment with CE from roasted cocoa beans could prevent the development of diabetes induced by STZ injection in rats. Society of Chemical Industry 2008-06 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/16379/1/Protective%20effect%20of%20polyphenol.pdf Mohd Mokhtar, Ruzaidi Azli and Mhd Jalil, Abbe Maleyki and Ismail, Amin and Abdul Ghani, Nawalyah and Hamid, Muhajir (2008) Protective effect of polyphenol-rich extract prepared from Malaysian cocoa (Theobroma cacao) on glucose levels and lipid profiles in streptozotocin-induced diabetic rats. Journal of the Science of Food and Agriculture, 88 (8). pp. 1442-1447. ISSN 0022-5142; ESSN: 1097-0010 http://onlinelibrary.wiley.com/wol1/doi/10.1002/jsfa.3236/abstract 10.1002/jsfa.3236 |
| spellingShingle | Mohd Mokhtar, Ruzaidi Azli Mhd Jalil, Abbe Maleyki Ismail, Amin Abdul Ghani, Nawalyah Hamid, Muhajir Protective effect of polyphenol-rich extract prepared from Malaysian cocoa (Theobroma cacao) on glucose levels and lipid profiles in streptozotocin-induced diabetic rats |
| title | Protective effect of polyphenol-rich extract prepared from Malaysian cocoa (Theobroma cacao) on glucose levels and lipid profiles in streptozotocin-induced diabetic rats |
| title_full | Protective effect of polyphenol-rich extract prepared from Malaysian cocoa (Theobroma cacao) on glucose levels and lipid profiles in streptozotocin-induced diabetic rats |
| title_fullStr | Protective effect of polyphenol-rich extract prepared from Malaysian cocoa (Theobroma cacao) on glucose levels and lipid profiles in streptozotocin-induced diabetic rats |
| title_full_unstemmed | Protective effect of polyphenol-rich extract prepared from Malaysian cocoa (Theobroma cacao) on glucose levels and lipid profiles in streptozotocin-induced diabetic rats |
| title_short | Protective effect of polyphenol-rich extract prepared from Malaysian cocoa (Theobroma cacao) on glucose levels and lipid profiles in streptozotocin-induced diabetic rats |
| title_sort | protective effect of polyphenol rich extract prepared from malaysian cocoa theobroma cacao on glucose levels and lipid profiles in streptozotocin induced diabetic rats |
| url | http://psasir.upm.edu.my/id/eprint/16379/1/Protective%20effect%20of%20polyphenol.pdf |
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