Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase.

Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase.

A bioassay-guided investigation of Melicope ptelefolia Champ ex Benth (Rutaceae) resulted in the identification of an acyphloroglucinol, 2,4,6-trihydroxy-3-geranylacetophenone or tHGA, as the active principle inhibiting soybean 15-LOX. The anti-inflammatory action was also demonstrated on human leuk...

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Bibliographic Details
Main Authors: Shaari, Khozirah, Suppaiah, Velan, Lam, Kok Wai, Stanslas, Johnson, Tejo, Bimo Ario, Israf Ali, Daud Ahmad, Abas, Faridah, Ismail, Intan Safinar, Shuaib, Nor Hasifi, Zareen, Seema, Lajis, Md. Nordin
Format: Article
Language:English
English
Published: Elsevier 2011
Online Access:http://psasir.upm.edu.my/id/eprint/25047/1/Bioassay-guided%20identification%20of%20an%20anti-inflammatory%20prenylated%20acylphloroglucinol%20from%20Melicope%20ptelefolia%20and%20molecular%20insights%20into%20its%20interaction%20with%205-lipoxygenase..pdf

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http://psasir.upm.edu.my/id/eprint/25047/1/Bioassay-guided%20identification%20of%20an%20anti-inflammatory%20prenylated%20acylphloroglucinol%20from%20Melicope%20ptelefolia%20and%20molecular%20insights%20into%20its%20interaction%20with%205-lipoxygenase..pdf

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