Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase.
A bioassay-guided investigation of Melicope ptelefolia Champ ex Benth (Rutaceae) resulted in the identification of an acyphloroglucinol, 2,4,6-trihydroxy-3-geranylacetophenone or tHGA, as the active principle inhibiting soybean 15-LOX. The anti-inflammatory action was also demonstrated on human leuk...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier
2011
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| Online Access: | http://psasir.upm.edu.my/id/eprint/25047/1/Bioassay-guided%20identification%20of%20an%20anti-inflammatory%20prenylated%20acylphloroglucinol%20from%20Melicope%20ptelefolia%20and%20molecular%20insights%20into%20its%20interaction%20with%205-lipoxygenase..pdf |