Phosphanegold(I) dithiocarbamates, R3PAu[SC(=S)N(iPr)CH2CH2OH] for R=Ph, Cy and Et: role of phosphane-bound R substituents upon in vitro cytotoxicity against MCF-7R breast cancer cells and cell death pathways
The synthesis and characterisation of R3PAu[S2CN(iPr)CH2CH2OH], for R = Ph (1), Cy (2) and Et (3)4, is reported. Compounds 1–3 are cytotoxic against the doxorubicin-resistant breast cancer cell line, MCF-7R, with 1 exhibiting greater potency and cytotoxicity than either of doxorubicin and cisplatin....
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Published: |
Elsevier
2013
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