β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells

β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells

β-Mangostin (βM) was isolated from Cratoxylum arborescens to investigate its anti-cancer effect in MCF-7 cells. βM induced apoptosis by down-regulation of Bcl2 and up-regulation of Bax, triggering the cytochrome c release from mitochondria to cytosol. The release of caspase-9 and -7 and consequently...

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Bibliographic Details
Main Authors: Syam, Suvitha, Bustamam, Ahmad, Abdullah, Rasedee, Sukari, Mohd Aspollah, Mohd Hashim, Najihah, Ghaderian, Mostafa, Rahmani, Mawardi, Mohan, Syam, Abdelwahab, Siddig Ibrahim, Mohd Ali, Hapipah
Format: Article
Language:English
Published: Elsevier 2014
Online Access:http://psasir.upm.edu.my/id/eprint/36671/1/%CE%B2.pdf

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http://psasir.upm.edu.my/id/eprint/36671/1/%CE%B2.pdf

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