The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling
The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight control, i.e. cells respond to a signal to proliferate, a...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Oxford University Press
2015
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/46664/1/The%20potential%20for%20chemical%20mixtures%20from%20the%20environment%20to%20enable%20the%20cancer%20hallmark%20of%20sustained%20proliferative%20signalling.pdf |
| _version_ | 1825929725563895808 |
|---|---|
| author | Engström, Wilhelm Darbre, Philippa Eriksson, Staffan Gulliver, Linda Hultman, Tove Karamouzis, Michalis V. Klaunig, James E. Mehta, Rekha Moorwood, Kim Sanderson, Thomas Sone, Hideko Vadgama, Pankaj Wagemaker, Gerard Ward, Andrew Singh, Neetu Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Colacci, Anna Maria Vaccari, Monica Mondello, Chiara Scovassi, A. Ivana Raju, Jayadev Abd. Hamid@ Abd. Razak, Roslida Memeo, Lorenzo Forte, Stefano Roy, Rabindra Woodrick, Jordan Salem, Hosni K. Ryan, Elizabeth P. Brown, Dustin G. Bisson, William H. |
| author_facet | Engström, Wilhelm Darbre, Philippa Eriksson, Staffan Gulliver, Linda Hultman, Tove Karamouzis, Michalis V. Klaunig, James E. Mehta, Rekha Moorwood, Kim Sanderson, Thomas Sone, Hideko Vadgama, Pankaj Wagemaker, Gerard Ward, Andrew Singh, Neetu Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Colacci, Anna Maria Vaccari, Monica Mondello, Chiara Scovassi, A. Ivana Raju, Jayadev Abd. Hamid@ Abd. Razak, Roslida Memeo, Lorenzo Forte, Stefano Roy, Rabindra Woodrick, Jordan Salem, Hosni K. Ryan, Elizabeth P. Brown, Dustin G. Bisson, William H. |
| author_sort | Engström, Wilhelm |
| collection | UPM |
| description | The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight control, i.e. cells respond to a signal to proliferate, and although most cells continue to proliferate into adult life, the multiplication ceases once the stimulatory signal disappears or if the cells are exposed to growth inhibitory signals. Under such circumstances, normal cells remain quiescent until they are stimulated to resume further proliferation. In contrast, tumour cells are unable to halt proliferation, either when subjected to growth inhibitory signals or in the absence of growth stimulatory signals. Environmental chemicals with carcinogenic potential may cause sustained cell proliferation by interfering with some cell proliferation control mechanisms committing cells to an indefinite proliferative span. |
| first_indexed | 2024-03-06T09:00:55Z |
| format | Article |
| id | upm.eprints-46664 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:00:55Z |
| publishDate | 2015 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | upm.eprints-466642018-02-22T07:40:30Z http://psasir.upm.edu.my/id/eprint/46664/ The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling Engström, Wilhelm Darbre, Philippa Eriksson, Staffan Gulliver, Linda Hultman, Tove Karamouzis, Michalis V. Klaunig, James E. Mehta, Rekha Moorwood, Kim Sanderson, Thomas Sone, Hideko Vadgama, Pankaj Wagemaker, Gerard Ward, Andrew Singh, Neetu Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Colacci, Anna Maria Vaccari, Monica Mondello, Chiara Scovassi, A. Ivana Raju, Jayadev Abd. Hamid@ Abd. Razak, Roslida Memeo, Lorenzo Forte, Stefano Roy, Rabindra Woodrick, Jordan Salem, Hosni K. Ryan, Elizabeth P. Brown, Dustin G. Bisson, William H. The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight control, i.e. cells respond to a signal to proliferate, and although most cells continue to proliferate into adult life, the multiplication ceases once the stimulatory signal disappears or if the cells are exposed to growth inhibitory signals. Under such circumstances, normal cells remain quiescent until they are stimulated to resume further proliferation. In contrast, tumour cells are unable to halt proliferation, either when subjected to growth inhibitory signals or in the absence of growth stimulatory signals. Environmental chemicals with carcinogenic potential may cause sustained cell proliferation by interfering with some cell proliferation control mechanisms committing cells to an indefinite proliferative span. Oxford University Press 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46664/1/The%20potential%20for%20chemical%20mixtures%20from%20the%20environment%20to%20enable%20the%20cancer%20hallmark%20of%20sustained%20proliferative%20signalling.pdf Engström, Wilhelm and Darbre, Philippa and Eriksson, Staffan and Gulliver, Linda and Hultman, Tove and Karamouzis, Michalis V. and Klaunig, James E. and Mehta, Rekha and Moorwood, Kim and Sanderson, Thomas and Sone, Hideko and Vadgama, Pankaj and Wagemaker, Gerard and Ward, Andrew and Singh, Neetu and Al-Mulla, Fahd and Al-Temaimi, Rabeah and Amedei, Amedeo and Colacci, Anna Maria and Vaccari, Monica and Mondello, Chiara and Scovassi, A. Ivana and Raju, Jayadev and Abd. Hamid@ Abd. Razak, Roslida and Memeo, Lorenzo and Forte, Stefano and Roy, Rabindra and Woodrick, Jordan and Salem, Hosni K. and Ryan, Elizabeth P. and Brown, Dustin G. and Bisson, William H. (2015) The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling. Carcinogenesis, 36 (suppl.). pp. 38-60. ISSN 0143-3334; ESSN: 1460-2180 http://carcin.oxfordjournals.org/ 10.1093/carcin/bgv030 |
| spellingShingle | Engström, Wilhelm Darbre, Philippa Eriksson, Staffan Gulliver, Linda Hultman, Tove Karamouzis, Michalis V. Klaunig, James E. Mehta, Rekha Moorwood, Kim Sanderson, Thomas Sone, Hideko Vadgama, Pankaj Wagemaker, Gerard Ward, Andrew Singh, Neetu Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Colacci, Anna Maria Vaccari, Monica Mondello, Chiara Scovassi, A. Ivana Raju, Jayadev Abd. Hamid@ Abd. Razak, Roslida Memeo, Lorenzo Forte, Stefano Roy, Rabindra Woodrick, Jordan Salem, Hosni K. Ryan, Elizabeth P. Brown, Dustin G. Bisson, William H. The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling |
| title | The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling |
| title_full | The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling |
| title_fullStr | The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling |
| title_full_unstemmed | The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling |
| title_short | The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling |
| title_sort | potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling |
| url | http://psasir.upm.edu.my/id/eprint/46664/1/The%20potential%20for%20chemical%20mixtures%20from%20the%20environment%20to%20enable%20the%20cancer%20hallmark%20of%20sustained%20proliferative%20signalling.pdf |
| work_keys_str_mv | AT engstromwilhelm thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT darbrephilippa thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT erikssonstaffan thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT gulliverlinda thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT hultmantove thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT karamouzismichalisv thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT klaunigjamese thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT mehtarekha thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT moorwoodkim thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT sandersonthomas thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT sonehideko thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT vadgamapankaj thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT wagemakergerard thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT wardandrew thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT singhneetu thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT almullafahd thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT altemaimirabeah thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT amedeiamedeo thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT colacciannamaria thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT vaccarimonica thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT mondellochiara thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT scovassiaivana thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT rajujayadev thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT abdhamidabdrazakroslida thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT memeolorenzo thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT fortestefano thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT royrabindra thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT woodrickjordan thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT salemhosnik thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT ryanelizabethp thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT browndusting thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT bissonwilliamh thepotentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT engstromwilhelm potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT darbrephilippa potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT erikssonstaffan potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT gulliverlinda potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT hultmantove potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT karamouzismichalisv potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT klaunigjamese potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT mehtarekha potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT moorwoodkim potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT sandersonthomas potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT sonehideko potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT vadgamapankaj potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT wagemakergerard potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT wardandrew potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT singhneetu potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT almullafahd potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT altemaimirabeah potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT amedeiamedeo potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT colacciannamaria potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT vaccarimonica potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT mondellochiara potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT scovassiaivana potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT rajujayadev potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT abdhamidabdrazakroslida potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT memeolorenzo potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT fortestefano potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT royrabindra potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT woodrickjordan potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT salemhosnik potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT ryanelizabethp potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT browndusting potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling AT bissonwilliamh potentialforchemicalmixturesfromtheenvironmenttoenablethecancerhallmarkofsustainedproliferativesignalling |