The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling
The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight control, i.e. cells respond to a signal to proliferate, a...
| প্রধান লেখক: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| বিন্যাস: | প্রবন্ধ |
| ভাষা: | English |
| প্রকাশিত: |
Oxford University Press
2015
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| অনলাইন ব্যবহার করুন: | http://psasir.upm.edu.my/id/eprint/46664/1/The%20potential%20for%20chemical%20mixtures%20from%20the%20environment%20to%20enable%20the%20cancer%20hallmark%20of%20sustained%20proliferative%20signalling.pdf |
| _version_ | 1825929725563895808 |
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| author | Engström, Wilhelm Darbre, Philippa Eriksson, Staffan Gulliver, Linda Hultman, Tove Karamouzis, Michalis V. Klaunig, James E. Mehta, Rekha Moorwood, Kim Sanderson, Thomas Sone, Hideko Vadgama, Pankaj Wagemaker, Gerard Ward, Andrew Singh, Neetu Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Colacci, Anna Maria Vaccari, Monica Mondello, Chiara Scovassi, A. Ivana Raju, Jayadev Abd. Hamid@ Abd. Razak, Roslida Memeo, Lorenzo Forte, Stefano Roy, Rabindra Woodrick, Jordan Salem, Hosni K. Ryan, Elizabeth P. Brown, Dustin G. Bisson, William H. |
| author_facet | Engström, Wilhelm Darbre, Philippa Eriksson, Staffan Gulliver, Linda Hultman, Tove Karamouzis, Michalis V. Klaunig, James E. Mehta, Rekha Moorwood, Kim Sanderson, Thomas Sone, Hideko Vadgama, Pankaj Wagemaker, Gerard Ward, Andrew Singh, Neetu Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Colacci, Anna Maria Vaccari, Monica Mondello, Chiara Scovassi, A. Ivana Raju, Jayadev Abd. Hamid@ Abd. Razak, Roslida Memeo, Lorenzo Forte, Stefano Roy, Rabindra Woodrick, Jordan Salem, Hosni K. Ryan, Elizabeth P. Brown, Dustin G. Bisson, William H. |
| author_sort | Engström, Wilhelm |
| collection | UPM |
| description | The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight control, i.e. cells respond to a signal to proliferate, and although most cells continue to proliferate into adult life, the multiplication ceases once the stimulatory signal disappears or if the cells are exposed to growth inhibitory signals. Under such circumstances, normal cells remain quiescent until they are stimulated to resume further proliferation. In contrast, tumour cells are unable to halt proliferation, either when subjected to growth inhibitory signals or in the absence of growth stimulatory signals. Environmental chemicals with carcinogenic potential may cause sustained cell proliferation by interfering with some cell proliferation control mechanisms committing cells to an indefinite proliferative span. |
| first_indexed | 2024-03-06T09:00:55Z |
| format | Article |
| id | upm.eprints-46664 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:00:55Z |
| publishDate | 2015 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | upm.eprints-466642018-02-22T07:40:30Z http://psasir.upm.edu.my/id/eprint/46664/ The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling Engström, Wilhelm Darbre, Philippa Eriksson, Staffan Gulliver, Linda Hultman, Tove Karamouzis, Michalis V. Klaunig, James E. Mehta, Rekha Moorwood, Kim Sanderson, Thomas Sone, Hideko Vadgama, Pankaj Wagemaker, Gerard Ward, Andrew Singh, Neetu Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Colacci, Anna Maria Vaccari, Monica Mondello, Chiara Scovassi, A. Ivana Raju, Jayadev Abd. Hamid@ Abd. Razak, Roslida Memeo, Lorenzo Forte, Stefano Roy, Rabindra Woodrick, Jordan Salem, Hosni K. Ryan, Elizabeth P. Brown, Dustin G. Bisson, William H. The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight control, i.e. cells respond to a signal to proliferate, and although most cells continue to proliferate into adult life, the multiplication ceases once the stimulatory signal disappears or if the cells are exposed to growth inhibitory signals. Under such circumstances, normal cells remain quiescent until they are stimulated to resume further proliferation. In contrast, tumour cells are unable to halt proliferation, either when subjected to growth inhibitory signals or in the absence of growth stimulatory signals. Environmental chemicals with carcinogenic potential may cause sustained cell proliferation by interfering with some cell proliferation control mechanisms committing cells to an indefinite proliferative span. Oxford University Press 2015 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/46664/1/The%20potential%20for%20chemical%20mixtures%20from%20the%20environment%20to%20enable%20the%20cancer%20hallmark%20of%20sustained%20proliferative%20signalling.pdf Engström, Wilhelm and Darbre, Philippa and Eriksson, Staffan and Gulliver, Linda and Hultman, Tove and Karamouzis, Michalis V. and Klaunig, James E. and Mehta, Rekha and Moorwood, Kim and Sanderson, Thomas and Sone, Hideko and Vadgama, Pankaj and Wagemaker, Gerard and Ward, Andrew and Singh, Neetu and Al-Mulla, Fahd and Al-Temaimi, Rabeah and Amedei, Amedeo and Colacci, Anna Maria and Vaccari, Monica and Mondello, Chiara and Scovassi, A. Ivana and Raju, Jayadev and Abd. Hamid@ Abd. Razak, Roslida and Memeo, Lorenzo and Forte, Stefano and Roy, Rabindra and Woodrick, Jordan and Salem, Hosni K. and Ryan, Elizabeth P. and Brown, Dustin G. and Bisson, William H. (2015) The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling. Carcinogenesis, 36 (suppl.). pp. 38-60. ISSN 0143-3334; ESSN: 1460-2180 http://carcin.oxfordjournals.org/ 10.1093/carcin/bgv030 |
| spellingShingle | Engström, Wilhelm Darbre, Philippa Eriksson, Staffan Gulliver, Linda Hultman, Tove Karamouzis, Michalis V. Klaunig, James E. Mehta, Rekha Moorwood, Kim Sanderson, Thomas Sone, Hideko Vadgama, Pankaj Wagemaker, Gerard Ward, Andrew Singh, Neetu Al-Mulla, Fahd Al-Temaimi, Rabeah Amedei, Amedeo Colacci, Anna Maria Vaccari, Monica Mondello, Chiara Scovassi, A. Ivana Raju, Jayadev Abd. Hamid@ Abd. Razak, Roslida Memeo, Lorenzo Forte, Stefano Roy, Rabindra Woodrick, Jordan Salem, Hosni K. Ryan, Elizabeth P. Brown, Dustin G. Bisson, William H. The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling |
| title | The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling |
| title_full | The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling |
| title_fullStr | The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling |
| title_full_unstemmed | The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling |
| title_short | The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling |
| title_sort | potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling |
| url | http://psasir.upm.edu.my/id/eprint/46664/1/The%20potential%20for%20chemical%20mixtures%20from%20the%20environment%20to%20enable%20the%20cancer%20hallmark%20of%20sustained%20proliferative%20signalling.pdf |
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