Insulinotropic activity of Tinospora crispa extract: effect on ß-cell Ca2+ handling
The mechanism of insulinotropic action of Tinospora crispa was investigated in vitro using an insulin-secreting clonal β-cell line, HIT-T15. The aqueous extract sensitizes the β-cell to extracellular Ca2+ and promotes intracellular Ca2+ accumulation which in turn causes increased insulin release. Th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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John Wiley & Sons
1998
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| Online Access: | http://psasir.upm.edu.my/id/eprint/51742/1/51742.pdf |
| _version_ | 1825930588604858368 |
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| author | Noor, Hamdan Ashcroft, Stephen J. H. |
| author_facet | Noor, Hamdan Ashcroft, Stephen J. H. |
| author_sort | Noor, Hamdan |
| collection | UPM |
| description | The mechanism of insulinotropic action of Tinospora crispa was investigated in vitro using an insulin-secreting clonal β-cell line, HIT-T15. The aqueous extract sensitizes the β-cell to extracellular Ca2+ and promotes intracellular Ca2+ accumulation which in turn causes increased insulin release. The increase in cytosolic Ca2+ concentration is due to stimulation of Ca2+ uptake from the extracellular medium and inhibition of Ca2+ efflux from the cytosol. That the mechanism of insulinotropic action of T. crispa is physiological suggests that the insulin secretagogue/s present in the extract could indeed be a potential source of a specific oral hypoglycaemic agent for the treatment of non-insulin-dependent diabetes mellitus. |
| first_indexed | 2024-03-06T09:13:50Z |
| format | Article |
| id | upm.eprints-51742 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T09:13:50Z |
| publishDate | 1998 |
| publisher | John Wiley & Sons |
| record_format | dspace |
| spelling | upm.eprints-517422017-09-06T07:52:33Z http://psasir.upm.edu.my/id/eprint/51742/ Insulinotropic activity of Tinospora crispa extract: effect on ß-cell Ca2+ handling Noor, Hamdan Ashcroft, Stephen J. H. The mechanism of insulinotropic action of Tinospora crispa was investigated in vitro using an insulin-secreting clonal β-cell line, HIT-T15. The aqueous extract sensitizes the β-cell to extracellular Ca2+ and promotes intracellular Ca2+ accumulation which in turn causes increased insulin release. The increase in cytosolic Ca2+ concentration is due to stimulation of Ca2+ uptake from the extracellular medium and inhibition of Ca2+ efflux from the cytosol. That the mechanism of insulinotropic action of T. crispa is physiological suggests that the insulin secretagogue/s present in the extract could indeed be a potential source of a specific oral hypoglycaemic agent for the treatment of non-insulin-dependent diabetes mellitus. John Wiley & Sons 1998 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/51742/1/51742.pdf Noor, Hamdan and Ashcroft, Stephen J. H. (1998) Insulinotropic activity of Tinospora crispa extract: effect on ß-cell Ca2+ handling. Phytotherapy Research, 12 (2). pp. 98-102. ISSN 0951-418X; ESSN: 1099-1573 http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1099-1573(199803)12:2%3C98::AID-PTR195%3E3.0.CO;2-F/abstract;jsessionid=9AAB77CEB7CD1C6EC2C2750437E98CE9.f04t04?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+12th+August+at+3%3A00+EDT+% 10.1002/(SICI)1099-1573(199803)12:2<98::AID-PTR195>3.0.CO;2-F |
| spellingShingle | Noor, Hamdan Ashcroft, Stephen J. H. Insulinotropic activity of Tinospora crispa extract: effect on ß-cell Ca2+ handling |
| title | Insulinotropic activity of Tinospora crispa extract: effect on ß-cell Ca2+ handling |
| title_full | Insulinotropic activity of Tinospora crispa extract: effect on ß-cell Ca2+ handling |
| title_fullStr | Insulinotropic activity of Tinospora crispa extract: effect on ß-cell Ca2+ handling |
| title_full_unstemmed | Insulinotropic activity of Tinospora crispa extract: effect on ß-cell Ca2+ handling |
| title_short | Insulinotropic activity of Tinospora crispa extract: effect on ß-cell Ca2+ handling |
| title_sort | insulinotropic activity of tinospora crispa extract effect on ss cell ca2 handling |
| url | http://psasir.upm.edu.my/id/eprint/51742/1/51742.pdf |
| work_keys_str_mv | AT noorhamdan insulinotropicactivityoftinosporacrispaextracteffectonßcellca2handling AT ashcroftstephenjh insulinotropicactivityoftinosporacrispaextracteffectonßcellca2handling |