IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation

IL-10 is an immunomodulatory cytokine with a critical role in limiting inflammation in immune-mediated pathologies. The mechanisms leading to IL-10 expression by CD4+ T cells are being elucidated, with several cytokines implicated. We explored the effect of IL-4 on the natural phenomenon of IL-10 pr...

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Bibliographic Details
Main Authors: Mitchell, Ruth E., Hassan, Masriana, Burton, Bronwen R., Britton, Graham, Hill, Elaine V., Verhagen, Johan, Wraith, David C.
Format: Article
Language:English
Published: Nature Publishing Group 2017
Online Access:http://psasir.upm.edu.my/id/eprint/62080/1/IL-4%20enhances%20IL-10%20production%20in.pdf