Effects of disrupting insulin-like growth factor-1 receptor (IGF-1R) signal transduction pathways with inhibitors of IGF-1R, EGFR, PI3K, MEK, and MTOR in breast cancer cell lines
Insulin-like growth factor receptor 1 (IGF-1R) has been shown to be overexpressed in patients with breast cancer. IGF-1R signaling pathway is known to activate numerous kinases, and proteins associated with cell growth and survival. Targeting these kinases and their pathways are promising ther...
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| Format: | Thesis |
| Language: | English |
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2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/76876/1/IB%202014%2027%20IR.pdf |