Limited expression of non-integrating CpG-free plasmid is associated with increased nucleosome enrichment
CpG-free pDNA was reported to facilitate sustained transgene expression with minimal inflammation in vivo as compared to CpG-containing pDNA. However, the expression potential and impact of CpG-free pDNA in in vitro model have never been described. Hence, in this study, we analyzed the transgene exp...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science
2020
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Online Access: | http://psasir.upm.edu.my/id/eprint/86578/1/Limited%20expression%20of%20non-integrating%20.pdf |