Location and size are useful features in diagnosing sessile serrated adenoma/polyp
Introduction: According to the predefined 2010 World Health Organisation criteria, serrated colonic polyps (SCP) are pathologically classified into hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P) with or without cytological dysplasia and traditional serrated adenoma (TSA). Sessile se...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/86588/1/2020110610534904_2020_0327.pdf |
| _version_ | 1825952228841619456 |
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| author | Hasnan Najib, Shahril Fikri Zul Mohamed Shabery, Noor Afidah Hussin, Huzlinda |
| author_facet | Hasnan Najib, Shahril Fikri Zul Mohamed Shabery, Noor Afidah Hussin, Huzlinda |
| author_sort | Hasnan Najib, Shahril Fikri Zul |
| collection | UPM |
| description | Introduction: According to the predefined 2010 World Health Organisation criteria, serrated colonic polyps (SCP) are pathologically classified into hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P) with or without cytological dysplasia and traditional serrated adenoma (TSA). Sessile serrated adenoma/polyp is acknowledged as a precursor of colorectal carcinoma through the serrated neoplastic pathway. Hyperplastic polyps display similar histological features to SSA/P, in comparison to other types of SCP. It is noteworthy to discriminate between HP and SSA/P, since only the latter has a malignant potential. Method: A total of 198 cases of SCP were identified and the slides were reexamined and reclassified accordingly. Analysis on the proportion of SSA/P among SCP and underdiagnosed cases of SSA/P was performed. The association between SSA/P and non-SSA/P with demographic data and colonoscopic findings were also studied. Results: From the 198 cases of SCP, 164, 29 and five cases were reclassified as HP, SSA/P and TSA respectively. Sixteen cases of SSA/P were underdiagnosed as HP. From among 29 cases of SSA/P, the majority were ≥ 65 years old (17; 58.6%), male (21; 72.4 %) and Chinese (17; 58.6%). Most of the SSA/P (16; 55.2 %) were located in the right colon and measured ≥ 10mm (9; 31%) in size. Location (p=0.004) and size (p=0.013) of the colonoscopic findings were significantly associated with SSA/P. Conclusion: Underdiagnosed cases of SSA/P among HP were identified most likely because of the resemblance of their histological features. The location and size of SCP may suggest the probability of SSA/P. |
| first_indexed | 2024-03-06T10:41:48Z |
| format | Article |
| id | upm.eprints-86588 |
| institution | Universiti Putra Malaysia |
| language | English |
| last_indexed | 2024-03-06T10:41:48Z |
| publishDate | 2020 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| record_format | dspace |
| spelling | upm.eprints-865882021-09-28T22:03:39Z http://psasir.upm.edu.my/id/eprint/86588/ Location and size are useful features in diagnosing sessile serrated adenoma/polyp Hasnan Najib, Shahril Fikri Zul Mohamed Shabery, Noor Afidah Hussin, Huzlinda Introduction: According to the predefined 2010 World Health Organisation criteria, serrated colonic polyps (SCP) are pathologically classified into hyperplastic polyp (HP), sessile serrated adenoma/polyp (SSA/P) with or without cytological dysplasia and traditional serrated adenoma (TSA). Sessile serrated adenoma/polyp is acknowledged as a precursor of colorectal carcinoma through the serrated neoplastic pathway. Hyperplastic polyps display similar histological features to SSA/P, in comparison to other types of SCP. It is noteworthy to discriminate between HP and SSA/P, since only the latter has a malignant potential. Method: A total of 198 cases of SCP were identified and the slides were reexamined and reclassified accordingly. Analysis on the proportion of SSA/P among SCP and underdiagnosed cases of SSA/P was performed. The association between SSA/P and non-SSA/P with demographic data and colonoscopic findings were also studied. Results: From the 198 cases of SCP, 164, 29 and five cases were reclassified as HP, SSA/P and TSA respectively. Sixteen cases of SSA/P were underdiagnosed as HP. From among 29 cases of SSA/P, the majority were ≥ 65 years old (17; 58.6%), male (21; 72.4 %) and Chinese (17; 58.6%). Most of the SSA/P (16; 55.2 %) were located in the right colon and measured ≥ 10mm (9; 31%) in size. Location (p=0.004) and size (p=0.013) of the colonoscopic findings were significantly associated with SSA/P. Conclusion: Underdiagnosed cases of SSA/P among HP were identified most likely because of the resemblance of their histological features. The location and size of SCP may suggest the probability of SSA/P. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020-11 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/86588/1/2020110610534904_2020_0327.pdf Hasnan Najib, Shahril Fikri Zul and Mohamed Shabery, Noor Afidah and Hussin, Huzlinda (2020) Location and size are useful features in diagnosing sessile serrated adenoma/polyp. Malaysian Journal of Medicine and Health Sciences, 16 (suppl. 9). 26 - 32. ISSN 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020110610534904_2020_0327.pdf |
| spellingShingle | Hasnan Najib, Shahril Fikri Zul Mohamed Shabery, Noor Afidah Hussin, Huzlinda Location and size are useful features in diagnosing sessile serrated adenoma/polyp |
| title | Location and size are useful features in diagnosing sessile serrated adenoma/polyp |
| title_full | Location and size are useful features in diagnosing sessile serrated adenoma/polyp |
| title_fullStr | Location and size are useful features in diagnosing sessile serrated adenoma/polyp |
| title_full_unstemmed | Location and size are useful features in diagnosing sessile serrated adenoma/polyp |
| title_short | Location and size are useful features in diagnosing sessile serrated adenoma/polyp |
| title_sort | location and size are useful features in diagnosing sessile serrated adenoma polyp |
| url | http://psasir.upm.edu.my/id/eprint/86588/1/2020110610534904_2020_0327.pdf |
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