Defining in vivo dose-response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach
Aristolochic acid I (AAI) is a well-known genotoxic kidney carcinogen. Metabolic conversion of AAI into the DNA-reactive aristolactam-nitrenium ion is involved in the mode of action of tumor formation. This study aims to predict in vivo AAI-DNA adduct formation in the kidney of rat, mouse and human...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
John Wiley & Sons
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/88350/1/ABSTRACT.pdf |