3,5-Bis(arylidene)-4-piperidonesaspotential dengue proteaseinhibitors

3,5-Bis(arylidene)-4-piperidonesaspotential dengue proteaseinhibitors

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Dengue isaseveremosquito-borneviralinfectioncausinghalfamilliondeathsannually. Dengue virusNS2B/NS3proteaseisavalidatedtargetforanti-denguedrugdesign.Aseriesofhitherto unreported 3,5-bis(arylidene)-4-piperidonesanalogues 4a–4j were synthesizedandscreened in silico against DENV2NS2B/NS3proteasetoe...

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Bibliographic Details
Main Authors: Osman, Hasnah, Idris, Nor Hashima, Kamarulzaman, Ezatul Ezleen, A.Wahab, Habibah, Hassan, Mohd. Zaheen
Format: Article
Published: Elsevier 2017
Subjects:
RS1-441 Pharmacy and materia medica

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