An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines
A series of hexahydro-1,6-naphthyridines were synthesized in good yields by the reaction of 3,5-bis[(E)-arylmethylidene] tetrahydro-4(1H)-pyridinones with cyanoacetamide in the presence of sodium ethoxide under simple mixing at ambient temperature for 6–10 minutes and were assayed for their acetyl...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | http://eprints.usm.my/38309/1/An_Expedient_Synthesis%2C_Acetylcholinesterase_Inhibitory_Activity%2C_and_Molecular.pdf |
| _version_ | 1825833827467001856 |
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| author | Almansour, Abdulrahman I. Kumar, Raju Suresh Arumugam, Natarajan Basiri, Alireza Kia, Yalda Ali, Mohamed Ashraf |
| author_facet | Almansour, Abdulrahman I. Kumar, Raju Suresh Arumugam, Natarajan Basiri, Alireza Kia, Yalda Ali, Mohamed Ashraf |
| author_sort | Almansour, Abdulrahman I. |
| collection | USM |
| description | A series of hexahydro-1,6-naphthyridines were synthesized in good yields by the reaction of 3,5-bis[(E)-arylmethylidene]
tetrahydro-4(1H)-pyridinones with cyanoacetamide in the presence of sodium ethoxide under simple mixing at ambient
temperature for 6–10 minutes and were assayed for their acetylcholinesterase (AChE) inhibitory activity using colorimetric Ellman’s
method. Compound 4e with methoxy substituent at ortho-position of the phenyl rings displayed the maximum inhibitory activity
with IC50 value of 2.12 |
| first_indexed | 2024-03-06T15:13:38Z |
| format | Article |
| id | usm.eprints-38309 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:13:38Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | usm.eprints-383092018-01-09T04:17:41Z http://eprints.usm.my/38309/ An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines Almansour, Abdulrahman I. Kumar, Raju Suresh Arumugam, Natarajan Basiri, Alireza Kia, Yalda Ali, Mohamed Ashraf QD1-999 Chemistry RS1-441 Pharmacy and materia medica A series of hexahydro-1,6-naphthyridines were synthesized in good yields by the reaction of 3,5-bis[(E)-arylmethylidene] tetrahydro-4(1H)-pyridinones with cyanoacetamide in the presence of sodium ethoxide under simple mixing at ambient temperature for 6–10 minutes and were assayed for their acetylcholinesterase (AChE) inhibitory activity using colorimetric Ellman’s method. Compound 4e with methoxy substituent at ortho-position of the phenyl rings displayed the maximum inhibitory activity with IC50 value of 2.12 Hindawi Publishing Corporation 2015 Article PeerReviewed application/pdf en http://eprints.usm.my/38309/1/An_Expedient_Synthesis%2C_Acetylcholinesterase_Inhibitory_Activity%2C_and_Molecular.pdf Almansour, Abdulrahman I. and Kumar, Raju Suresh and Arumugam, Natarajan and Basiri, Alireza and Kia, Yalda and Ali, Mohamed Ashraf (2015) An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines. BioMed Research International, 2015 (965987). pp. 1-9. ISSN 2314-6133 http://dx.doi.org/10.1155/2015/965987 |
| spellingShingle | QD1-999 Chemistry RS1-441 Pharmacy and materia medica Almansour, Abdulrahman I. Kumar, Raju Suresh Arumugam, Natarajan Basiri, Alireza Kia, Yalda Ali, Mohamed Ashraf An Expedient Synthesis, Acetylcholinesterase Inhibitory Activity, and Molecular Modeling Study of Highly Functionalized Hexahydro-1,6-naphthyridines |
| title | An Expedient Synthesis, Acetylcholinesterase
Inhibitory Activity, and Molecular Modeling Study of Highly
Functionalized Hexahydro-1,6-naphthyridines |
| title_full | An Expedient Synthesis, Acetylcholinesterase
Inhibitory Activity, and Molecular Modeling Study of Highly
Functionalized Hexahydro-1,6-naphthyridines |
| title_fullStr | An Expedient Synthesis, Acetylcholinesterase
Inhibitory Activity, and Molecular Modeling Study of Highly
Functionalized Hexahydro-1,6-naphthyridines |
| title_full_unstemmed | An Expedient Synthesis, Acetylcholinesterase
Inhibitory Activity, and Molecular Modeling Study of Highly
Functionalized Hexahydro-1,6-naphthyridines |
| title_short | An Expedient Synthesis, Acetylcholinesterase
Inhibitory Activity, and Molecular Modeling Study of Highly
Functionalized Hexahydro-1,6-naphthyridines |
| title_sort | expedient synthesis acetylcholinesterase inhibitory activity and molecular modeling study of highly functionalized hexahydro 1 6 naphthyridines |
| topic | QD1-999 Chemistry RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/38309/1/An_Expedient_Synthesis%2C_Acetylcholinesterase_Inhibitory_Activity%2C_and_Molecular.pdf |
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