Contribution of BCR-ABL kinase domain mutations to imatinib mesylate resistance in Philadelphia chromosome positive Malaysian chronic myeloid leukemia patients

Contribution of BCR-ABL kinase domain mutations to imatinib mesylate resistance in Philadelphia chromosome positive Malaysian chronic myeloid leukemia patients

Development of resistance to imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients is mediated by different mechanisms that can be classified as BCR-ABL dependent or BCR-ABL independent pathways. BCR-ABL dependent mechanisms are most frequently associated with point mutations in t...

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Bibliographic Details
Main Authors: Elias, Marjanu Hikmah, Baba, Abdul Aziz, Husin, Azlan, Abdullah, Abu Dzarr, Hassan, Rosline, Goh, Ai Sim, Abdul Wahid, S. Fadilah, Ankathil, Ravindran
Format: Article
Language:English
Published: PAGEpress 2012
Subjects:
R5-920 Medicine (General)
Online Access:http://eprints.usm.my/38527/1/Contribution_of_BCR-ABL_kinase_domain_mutations_to_imatinib_mesylate_resistance_in_Philadelphia_chromosome.pdf

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http://eprints.usm.my/38527/1/Contribution_of_BCR-ABL_kinase_domain_mutations_to_imatinib_mesylate_resistance_in_Philadelphia_chromosome.pdf

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