Screening For Small Molecule Inhibitors Of p27Kip1 Degradation

In a majority of human cancers, the cyclin-dependent kinase (CDK) inhibitor p27Kip1 is commonly found to be deregulated due to proteolysis by the ubiquitin-proteasome pathway involving the SCFSkp2 E3 ligase. Although proteasome inhibitors act to stabilize p27Kip1, small molecules agents inhibiting t...

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Bibliografische gegevens
Hoofdauteur: Ooi, Li Ching
Formaat: Thesis
Taal:English
Gepubliceerd in: 2012
Onderwerpen:
Online toegang:http://eprints.usm.my/44880/1/OOI%20LI%20CHING.pdf