Large arterial compliance and mirovascular function in women with gestational diabetes
Background: Post-occlusive skin reactive hyperaemia (PORH) is a model used to assess microvascular reactivity. This study aims to compare PORH response among pregnant hypercholesterolaemic patients with age and gestational age-matched controls. Methods: This cross sectional study involved 17 hype...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia
2011
|
Subjects: | |
Online Access: | http://eprints.usm.my/50050/1/DR.%20GHULAM%20RASOOL-EPRINTS.pdf |
_version_ | 1797012343293476864 |
---|---|
author | Mahmood, Nik Mohd Zaki Nik Ghaffar, Nor Aliza Halim, Ahmad Sukari Halim, Abdul |
author_facet | Mahmood, Nik Mohd Zaki Nik Ghaffar, Nor Aliza Halim, Ahmad Sukari Halim, Abdul |
author_sort | Mahmood, Nik Mohd Zaki Nik |
collection | USM |
description | Background: Post-occlusive skin reactive hyperaemia (PORH) is a model used to
assess microvascular reactivity. This study aims to compare PORH response among pregnant
hypercholesterolaemic patients with age and gestational age-matched controls.
Methods: This cross sectional study involved 17 hypercholesterolaemic, pregnant women
and 20 pregnant controls entering their early third trimester. Laser Doppler fluximetry (LDF) was
used to measure skin perfusion. The process of PORH was performed by occluding the upper arm
with an occlusion cuff at 200 mmHg for 3 minutes. Sld.n perfusion was recorded before, during, and
after occlusion release. Baseline perfusiOn, time to achieve peak perfusion (Tp), peak perfusion after
occJusion release (PORHpeak), and maximum change in perfusion due to occlusion (PORHma) were
recorded. .
Results: Serum total cholesterol (TC) was significantly different (P < o.oo1) between the 2
groups: 7.25 (SEM 0.18) mmoi/L for hypercholesterolaemic women and 5.54 (SEM 0.15) mmoi/L for
the control group. There were no significant differences in their baseline, PORHpe~~k' and PORH ... o.x'
However, Tp in the hypercholesterolaemic group was significantly increased (P = 0.024) compared
"'ith the controls at 14.9 (SEM o.6) seconds and 13.1 (SEM o.s) seconds, respectively.
Conclusion: Pregnant hypercholesterolaemic patients showed an abnormal
microvascular reactivity response. Tp with ischemia was significantly increased compared with
nonnocholesterolaemic controls. |
first_indexed | 2024-03-06T15:46:24Z |
format | Article |
id | usm.eprints-50050 |
institution | Universiti Sains Malaysia |
language | English |
last_indexed | 2024-03-06T15:46:24Z |
publishDate | 2011 |
publisher | Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia |
record_format | dspace |
spelling | usm.eprints-500502021-09-26T08:43:40Z http://eprints.usm.my/50050/ Large arterial compliance and mirovascular function in women with gestational diabetes Mahmood, Nik Mohd Zaki Nik Ghaffar, Nor Aliza Halim, Ahmad Sukari Halim, Abdul R Medicine Background: Post-occlusive skin reactive hyperaemia (PORH) is a model used to assess microvascular reactivity. This study aims to compare PORH response among pregnant hypercholesterolaemic patients with age and gestational age-matched controls. Methods: This cross sectional study involved 17 hypercholesterolaemic, pregnant women and 20 pregnant controls entering their early third trimester. Laser Doppler fluximetry (LDF) was used to measure skin perfusion. The process of PORH was performed by occluding the upper arm with an occlusion cuff at 200 mmHg for 3 minutes. Sld.n perfusion was recorded before, during, and after occlusion release. Baseline perfusiOn, time to achieve peak perfusion (Tp), peak perfusion after occJusion release (PORHpeak), and maximum change in perfusion due to occlusion (PORHma) were recorded. . Results: Serum total cholesterol (TC) was significantly different (P < o.oo1) between the 2 groups: 7.25 (SEM 0.18) mmoi/L for hypercholesterolaemic women and 5.54 (SEM 0.15) mmoi/L for the control group. There were no significant differences in their baseline, PORHpe~~k' and PORH ... o.x' However, Tp in the hypercholesterolaemic group was significantly increased (P = 0.024) compared "'ith the controls at 14.9 (SEM o.6) seconds and 13.1 (SEM o.s) seconds, respectively. Conclusion: Pregnant hypercholesterolaemic patients showed an abnormal microvascular reactivity response. Tp with ischemia was significantly increased compared with nonnocholesterolaemic controls. Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia 2011 Article PeerReviewed application/pdf en http://eprints.usm.my/50050/1/DR.%20GHULAM%20RASOOL-EPRINTS.pdf Mahmood, Nik Mohd Zaki Nik and Ghaffar, Nor Aliza and Halim, Ahmad Sukari and Halim, Abdul (2011) Large arterial compliance and mirovascular function in women with gestational diabetes. Large .arterial compliance and mirovascular function in women with gestational diabetes. |
spellingShingle | R Medicine Mahmood, Nik Mohd Zaki Nik Ghaffar, Nor Aliza Halim, Ahmad Sukari Halim, Abdul Large arterial compliance and mirovascular function in women with gestational diabetes |
title | Large arterial compliance and
mirovascular function in women with
gestational diabetes |
title_full | Large arterial compliance and
mirovascular function in women with
gestational diabetes |
title_fullStr | Large arterial compliance and
mirovascular function in women with
gestational diabetes |
title_full_unstemmed | Large arterial compliance and
mirovascular function in women with
gestational diabetes |
title_short | Large arterial compliance and
mirovascular function in women with
gestational diabetes |
title_sort | large arterial compliance and mirovascular function in women with gestational diabetes |
topic | R Medicine |
url | http://eprints.usm.my/50050/1/DR.%20GHULAM%20RASOOL-EPRINTS.pdf |
work_keys_str_mv | AT mahmoodnikmohdzakinik largearterialcomplianceandmirovascularfunctioninwomenwithgestationaldiabetes AT ghaffarnoraliza largearterialcomplianceandmirovascularfunctioninwomenwithgestationaldiabetes AT halimahmadsukari largearterialcomplianceandmirovascularfunctioninwomenwithgestationaldiabetes AT halimabdul largearterialcomplianceandmirovascularfunctioninwomenwithgestationaldiabetes |