Large arterial compliance and mirovascular function in women with gestational diabetes

Background: Post-occlusive skin reactive hyperaemia (PORH) is a model used to assess microvascular reactivity. This study aims to compare PORH response among pregnant hypercholesterolaemic patients with age and gestational age-matched controls. Methods: This cross sectional study involved 17 hype...

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Main Authors: Mahmood, Nik Mohd Zaki Nik, Ghaffar, Nor Aliza, Halim, Ahmad Sukari, Halim, Abdul
Format: Article
Language:English
Published: Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia 2011
Subjects:
Online Access:http://eprints.usm.my/50050/1/DR.%20GHULAM%20RASOOL-EPRINTS.pdf
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author Mahmood, Nik Mohd Zaki Nik
Ghaffar, Nor Aliza
Halim, Ahmad Sukari
Halim, Abdul
author_facet Mahmood, Nik Mohd Zaki Nik
Ghaffar, Nor Aliza
Halim, Ahmad Sukari
Halim, Abdul
author_sort Mahmood, Nik Mohd Zaki Nik
collection USM
description Background: Post-occlusive skin reactive hyperaemia (PORH) is a model used to assess microvascular reactivity. This study aims to compare PORH response among pregnant hypercholesterolaemic patients with age and gestational age-matched controls. Methods: This cross sectional study involved 17 hypercholesterolaemic, pregnant women and 20 pregnant controls entering their early third trimester. Laser Doppler fluximetry (LDF) was used to measure skin perfusion. The process of PORH was performed by occluding the upper arm with an occlusion cuff at 200 mmHg for 3 minutes. Sld.n perfusion was recorded before, during, and after occlusion release. Baseline perfusiOn, time to achieve peak perfusion (Tp), peak perfusion after occJusion release (PORHpeak), and maximum change in perfusion due to occlusion (PORHma) were recorded. . Results: Serum total cholesterol (TC) was significantly different (P < o.oo1) between the 2 groups: 7.25 (SEM 0.18) mmoi/L for hypercholesterolaemic women and 5.54 (SEM 0.15) mmoi/L for the control group. There were no significant differences in their baseline, PORHpe~~k' and PORH ... o.x' However, Tp in the hypercholesterolaemic group was significantly increased (P = 0.024) compared "'ith the controls at 14.9 (SEM o.6) seconds and 13.1 (SEM o.s) seconds, respectively. Conclusion: Pregnant hypercholesterolaemic patients showed an abnormal microvascular reactivity response. Tp with ischemia was significantly increased compared with nonnocholesterolaemic controls.
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spelling usm.eprints-500502021-09-26T08:43:40Z http://eprints.usm.my/50050/ Large arterial compliance and mirovascular function in women with gestational diabetes Mahmood, Nik Mohd Zaki Nik Ghaffar, Nor Aliza Halim, Ahmad Sukari Halim, Abdul R Medicine Background: Post-occlusive skin reactive hyperaemia (PORH) is a model used to assess microvascular reactivity. This study aims to compare PORH response among pregnant hypercholesterolaemic patients with age and gestational age-matched controls. Methods: This cross sectional study involved 17 hypercholesterolaemic, pregnant women and 20 pregnant controls entering their early third trimester. Laser Doppler fluximetry (LDF) was used to measure skin perfusion. The process of PORH was performed by occluding the upper arm with an occlusion cuff at 200 mmHg for 3 minutes. Sld.n perfusion was recorded before, during, and after occlusion release. Baseline perfusiOn, time to achieve peak perfusion (Tp), peak perfusion after occJusion release (PORHpeak), and maximum change in perfusion due to occlusion (PORHma) were recorded. . Results: Serum total cholesterol (TC) was significantly different (P < o.oo1) between the 2 groups: 7.25 (SEM 0.18) mmoi/L for hypercholesterolaemic women and 5.54 (SEM 0.15) mmoi/L for the control group. There were no significant differences in their baseline, PORHpe~~k' and PORH ... o.x' However, Tp in the hypercholesterolaemic group was significantly increased (P = 0.024) compared "'ith the controls at 14.9 (SEM o.6) seconds and 13.1 (SEM o.s) seconds, respectively. Conclusion: Pregnant hypercholesterolaemic patients showed an abnormal microvascular reactivity response. Tp with ischemia was significantly increased compared with nonnocholesterolaemic controls. Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia 2011 Article PeerReviewed application/pdf en http://eprints.usm.my/50050/1/DR.%20GHULAM%20RASOOL-EPRINTS.pdf Mahmood, Nik Mohd Zaki Nik and Ghaffar, Nor Aliza and Halim, Ahmad Sukari and Halim, Abdul (2011) Large arterial compliance and mirovascular function in women with gestational diabetes. Large .arterial compliance and mirovascular function in women with gestational diabetes.
spellingShingle R Medicine
Mahmood, Nik Mohd Zaki Nik
Ghaffar, Nor Aliza
Halim, Ahmad Sukari
Halim, Abdul
Large arterial compliance and mirovascular function in women with gestational diabetes
title Large arterial compliance and mirovascular function in women with gestational diabetes
title_full Large arterial compliance and mirovascular function in women with gestational diabetes
title_fullStr Large arterial compliance and mirovascular function in women with gestational diabetes
title_full_unstemmed Large arterial compliance and mirovascular function in women with gestational diabetes
title_short Large arterial compliance and mirovascular function in women with gestational diabetes
title_sort large arterial compliance and mirovascular function in women with gestational diabetes
topic R Medicine
url http://eprints.usm.my/50050/1/DR.%20GHULAM%20RASOOL-EPRINTS.pdf
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AT halimahmadsukari largearterialcomplianceandmirovascularfunctioninwomenwithgestationaldiabetes
AT halimabdul largearterialcomplianceandmirovascularfunctioninwomenwithgestationaldiabetes