Conformational transitions of proteins engaged in dna double-strand break repair, analysed by trytophan flourescence emission and fret
We analysed protein–DNA and protein–protein interactions relevant to the repair of DNA DSBs (double-strand breaks) by NHEJ (non-homologous end-joining). Conformational transitions in mammalian DNA ligases III (LigIII) and IV (LigIV), as well as in PARP-1 [poly(ADP-ribose) polymerase-1], were analyse...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Published: |
Biochemical Society
2012
|
Subjects: |