Conformational transitions of proteins engaged in dna double-strand break repair, analysed by trytophan flourescence emission and fret

We analysed protein–DNA and protein–protein interactions relevant to the repair of DNA DSBs (double-strand breaks) by NHEJ (non-homologous end-joining). Conformational transitions in mammalian DNA ligases III (LigIII) and IV (LigIV), as well as in PARP-1 [poly(ADP-ribose) polymerase-1], were analyse...

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Bibliographic Details
Main Authors: Stankova, Katia, Ivanova, Katia, Mladenov, Emil, Rosidi, Bustanur, Sharma, Aparna, Boteva, Rayna, Iliakis, George
Format: Article
Published: Biochemical Society 2012
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