Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury

Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury

Objectives:Mutations in PTEN inducible kinase-1 (PINK1) induce mitochondrial dysfunction in dopaminergic neurons resulting in an inherited form of Parkinson's disease. Although PINK1 is present in the heart its exact role there is unclear. We hypothesized that PINK1 protects the heart against a...

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Bibliographic Details
Main Authors: Siddall, Hilary K., Yellon, Derek M., Ong, Sang Bing, Mukherjee, Uma A., Burke, Niall, Hall, Andrew R., Angelova, Plamena R., Ludtmann, Marthe H. R., Deas, Emma, Davidson, Sean M., Mocanu, Mihaela M., Hausenloy, Derek J.
Format: Article
Language:English
Published: Plos One 2013
Subjects:
R Medicine (General)
Online Access:http://eprints.utm.my/49047/1/OngSangBing2013_LossofPINK1increases.pdf

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http://eprints.utm.my/49047/1/OngSangBing2013_LossofPINK1increases.pdf

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