Determination of structure of precursor of ibuprofen: purification and analysis
(S)-2-(p-isobutylphenyl) propanoic acid, so called ibuprofen, is one of the most popular anti-inflammatory agents. An efficient cross-coupling reaction of organozinc compound of ethyl 2-bromoacrylate, prepared by the reaction of hightly reactive zinc was carried out with aryl iodide to synthesize 2-...
| Main Authors: | , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
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2004
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| Online Access: | http://eprints.utm.my/5240/1/AishahAbdulJalil2004_DeterminationOfStructureOfPrecursorOfIbuprofen.pdf |
| _version_ | 1825909699998908416 |
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| author | Abdul Jalil, Aishah Kurono, Nobuhito Tokuda, Masao |
| author_facet | Abdul Jalil, Aishah Kurono, Nobuhito Tokuda, Masao |
| author_sort | Abdul Jalil, Aishah |
| collection | ePrints |
| description | (S)-2-(p-isobutylphenyl) propanoic acid, so called ibuprofen, is one of the most popular anti-inflammatory agents. An efficient cross-coupling reaction of organozinc compound of ethyl 2-bromoacrylate, prepared by the reaction of hightly reactive zinc was carried out with aryl iodide to synthesize 2-(4-isobutylphenyl)-propenoate, a precursor of ibuprofen. Highly reactive zinc metal (EGZn/Naph) was readily prepared by electrolysis of a DMF solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. The synthesized precursor of ibuprofen was purified by thin layer chromatography on silica gel and its structure was confirmed by elemental analysis, mass, IR, 1H NMR and 13C NMR spectroscopic analysis. |
| first_indexed | 2024-03-05T18:06:04Z |
| format | Conference or Workshop Item |
| id | utm.eprints-5240 |
| institution | Universiti Teknologi Malaysia - ePrints |
| language | English |
| last_indexed | 2024-03-05T18:06:04Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | utm.eprints-52402017-09-10T06:40:40Z http://eprints.utm.my/5240/ Determination of structure of precursor of ibuprofen: purification and analysis Abdul Jalil, Aishah Kurono, Nobuhito Tokuda, Masao T Technology (General) (S)-2-(p-isobutylphenyl) propanoic acid, so called ibuprofen, is one of the most popular anti-inflammatory agents. An efficient cross-coupling reaction of organozinc compound of ethyl 2-bromoacrylate, prepared by the reaction of hightly reactive zinc was carried out with aryl iodide to synthesize 2-(4-isobutylphenyl)-propenoate, a precursor of ibuprofen. Highly reactive zinc metal (EGZn/Naph) was readily prepared by electrolysis of a DMF solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. The synthesized precursor of ibuprofen was purified by thin layer chromatography on silica gel and its structure was confirmed by elemental analysis, mass, IR, 1H NMR and 13C NMR spectroscopic analysis. 2004 Conference or Workshop Item PeerReviewed application/pdf en http://eprints.utm.my/5240/1/AishahAbdulJalil2004_DeterminationOfStructureOfPrecursorOfIbuprofen.pdf Abdul Jalil, Aishah and Kurono, Nobuhito and Tokuda, Masao (2004) Determination of structure of precursor of ibuprofen: purification and analysis. In: Simposium Kimia Analisis Malaysia Ke-17 (SKAM-17), 24-26 Ogos 2004, Swiss-Garden Resort, Pantai Balok, Kuantan. (Submitted) |
| spellingShingle | T Technology (General) Abdul Jalil, Aishah Kurono, Nobuhito Tokuda, Masao Determination of structure of precursor of ibuprofen: purification and analysis |
| title | Determination of structure of precursor of ibuprofen:
purification and analysis
|
| title_full | Determination of structure of precursor of ibuprofen:
purification and analysis
|
| title_fullStr | Determination of structure of precursor of ibuprofen:
purification and analysis
|
| title_full_unstemmed | Determination of structure of precursor of ibuprofen:
purification and analysis
|
| title_short | Determination of structure of precursor of ibuprofen:
purification and analysis
|
| title_sort | determination of structure of precursor of ibuprofen purification and analysis |
| topic | T Technology (General) |
| url | http://eprints.utm.my/5240/1/AishahAbdulJalil2004_DeterminationOfStructureOfPrecursorOfIbuprofen.pdf |
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