Immunotherapeutic implications of negative regulation by protein tyrosine phosphatases in T cells: the emerging cases of PTP1B and TCPTP

Immunotherapeutic implications of negative regulation by protein tyrosine phosphatases in T cells: the emerging cases of PTP1B and TCPTP

In the context of inflammation, T cell activation occurs by the concerted signals of the T cell receptor (TCR), co-stimulatory receptors ligation, and a pro-inflammatory cytokine microenvironment. Fine-tuning these signals is crucial to maintain T cell homeostasis and prevent self-reactivity while o...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs: Luis Alberto Perez-Quintero, Belma Melda Abidin, Michel L. Tremblay
Formaat: Artikel
Taal:English
Gepubliceerd in: Frontiers Media S.A. 2024-04-01
Reeks:Frontiers in Medicine
Onderwerpen:
protein tyrosine phosphatases
T cells
immunotherapy
signaling
PTP1B (PTPN1)
TCPTP (PTPN2)
Online toegang:https://www.frontiersin.org/articles/10.3389/fmed.2024.1364778/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2024.1364778/full

Gelijkaardige items