Pleiotropic expression quantitative trait loci are enriched in enhancers and transcription factor binding sites and impact more genes

Pleiotropic expression quantitative trait loci are enriched in enhancers and transcription factor binding sites and impact more genes

Integrating expression quantitative trait loci (eQTL) data with genome-wide association studies (GWAS) enables the discovery of pleiotropic gene regulatory variants that influence a wide range of traits and disease susceptibilities. However, a comprehensive understanding of the distribution of pleio...

Full description

Bibliographic Details
Main Authors: Aitor González, Pascale Paul
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Genome-wide associations studies (GWAS), expression quantitative trait loci (eQTL)
Pleiotropy
Colocalization
Online Access:http://www.sciencedirect.com/science/article/pii/S200103702400391X

Internet

http://www.sciencedirect.com/science/article/pii/S200103702400391X

Similar Items