Enhanced Cancer Therapy Using an Engineered Designer Cytokine Alone and in Combination With an Immune Checkpoint Inhibitor

Enhanced Cancer Therapy Using an Engineered Designer Cytokine Alone and in Combination With an Immune Checkpoint Inhibitor

melanoma differentiation associated gene-7 or Interleukin-24 (mda-7, IL-24) displays expansive anti-tumor activity without harming corresponding normal cells/tissues. This anticancer activity has been documented in vitro and in vivo in multiple preclinical animal models, as well as in patients with...

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Bibliographic Details
Main Authors: Anjan K. Pradhan, Praveen Bhoopathi, Santanu Maji, Amit Kumar, Chunqing Guo, Padmanabhan Mannangatti, Jiong Li, Xiang-Yang Wang, Devanand Sarkar, Luni Emdad, Swadesh K. Das, Paul B. Fisher
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
secretory motif
mda-7 (IL-24)
M7S (IL-24S)
insulin signal peptide; PD-L1
melanoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.812560/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.812560/full

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