The role of the Cx43/Cx45 gap junction voltage gating on wave propagation and arrhythmogenic activity in cardiac tissue

Abstract Gap junctions (GJs) formed of connexin (Cx) protein are the main conduits of electrical signals in the heart. Studies indicate that the transitional zone of the atrioventricular (AV) node contains heterotypic Cx43/Cx45 GJ channels which are highly sensitive to transjunctional voltage (Vj)....

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Kestutis Maciunas, Mindaugas Snipas, Tadas Kraujalis, Lina Kraujalienė, Alexander V. Panfilov
Format: Artikel
Sprache:English
Veröffentlicht: Nature Portfolio 2023-09-01
Schriftenreihe:Scientific Reports
Online Zugang:https://doi.org/10.1038/s41598-023-41796-w