Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway

Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway

Background: It has been demonstrated that vitamin D deficiency is associated with an increased risk of patients developing lumbar disc herniation. However, intervertebral disc degeneration caused by active vitamin D deficiency has not been reported. Thus, the purpose of this study was to e investiga...

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Bibliographic Details
Main Authors: Peng Wang, Cuicui Yang, Jinhong Lu, Yongxin Ren, David Goltzman, Dengshun Miao
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Orthopaedic Translation
Subjects:
Vitamin D
Vitamin D receptor
Sirt1
Intervertebral disc degeneration
NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X23000268

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http://www.sciencedirect.com/science/article/pii/S2214031X23000268

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