Axon demyelination and degeneration in a zebrafish spastizin model of hereditary spastic paraplegia

Axon demyelination and degeneration in a zebrafish spastizin model of hereditary spastic paraplegia

Hereditary spastic paraplegias (HSPs) are a diverse set of neurological disorders characterized by progressive spasticity and weakness in the lower limbs caused by damage to the axons of the corticospinal tract. More than 88 genetic mutations have been associated with HSP, yet the mechanisms underly...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Vranda Garg, Selina André, Luisa Heyer, Gudrun Kracht, Torben Ruhwedel, Patricia Scholz, Till Ischebeck, Hauke B. Werner, Christian Dullin, Jacob Engelmann, Wiebke Möbius, Martin C. Göpfert, Roland Dosch, Bart R. H. Geurten
Μορφή: Άρθρο
Γλώσσα:English
Έκδοση: The Royal Society 2024-11-01
Σειρά:Open Biology
Θέματα:
Hereditary spastic paraplegia (HSP)
spastizin
zebrafish
lower limb spasticity
mauthner neurons
C-start escape response
Διαθέσιμο Online:https://royalsocietypublishing.org/doi/10.1098/rsob.240100

Διαδίκτυο

https://royalsocietypublishing.org/doi/10.1098/rsob.240100

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