Cold stimuli, hot topic: An updated review on the biological activity of menthol in relation to inflammation

BackgroundRising incidence of inflammation-related diseases is an increasing concern nowadays. However, while menthol is a wildly-used and efficacious complementary medicine, its pharmacological mechanism still remains uncertain. Superimposed upon that, the aim of this review is to summarize the con...

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Main Authors: Haojin Cheng, Xuemei An
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1023746/full
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author Haojin Cheng
Xuemei An
author_facet Haojin Cheng
Xuemei An
author_sort Haojin Cheng
collection DOAJ
description BackgroundRising incidence of inflammation-related diseases is an increasing concern nowadays. However, while menthol is a wildly-used and efficacious complementary medicine, its pharmacological mechanism still remains uncertain. Superimposed upon that, the aim of this review is to summarize the contemporary evidence of menthol’s anti-inflammatory activity.MethodsUsing the pharmacopeias and electronic databases, including Web of Science, PubMed, and CNKI, this study analyzed the relevant research articles and review articles from 2002 to 2022 and concluded those results and conjectures to finish this article.ResultsThe decrease in pro-inflammatory cytokines and related inflammatory markers, as well as associated pathway activation, was found to play the greatest role in the protective effects of menthol against inflammatory damage or association with protection against chronic inflammation.ConclusionThis review mainly concludes the progress in menthol’s anti-inflammatory activity. Further studies are needed to establish relationships between the mechanisms of action and to clarify the clinical relevance of any anti-inflammatory effects.
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spelling doaj.art-28fe24f8052244e28e68853995fd0dc52022-12-22T03:36:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.10237461023746Cold stimuli, hot topic: An updated review on the biological activity of menthol in relation to inflammationHaojin Cheng0Xuemei An1College of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaNursing Department, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaBackgroundRising incidence of inflammation-related diseases is an increasing concern nowadays. However, while menthol is a wildly-used and efficacious complementary medicine, its pharmacological mechanism still remains uncertain. Superimposed upon that, the aim of this review is to summarize the contemporary evidence of menthol’s anti-inflammatory activity.MethodsUsing the pharmacopeias and electronic databases, including Web of Science, PubMed, and CNKI, this study analyzed the relevant research articles and review articles from 2002 to 2022 and concluded those results and conjectures to finish this article.ResultsThe decrease in pro-inflammatory cytokines and related inflammatory markers, as well as associated pathway activation, was found to play the greatest role in the protective effects of menthol against inflammatory damage or association with protection against chronic inflammation.ConclusionThis review mainly concludes the progress in menthol’s anti-inflammatory activity. Further studies are needed to establish relationships between the mechanisms of action and to clarify the clinical relevance of any anti-inflammatory effects.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1023746/fullmentholinflammationreviewTRPM-8natural products
spellingShingle Haojin Cheng
Xuemei An
Cold stimuli, hot topic: An updated review on the biological activity of menthol in relation to inflammation
Frontiers in Immunology
menthol
inflammation
review
TRPM-8
natural products
title Cold stimuli, hot topic: An updated review on the biological activity of menthol in relation to inflammation
title_full Cold stimuli, hot topic: An updated review on the biological activity of menthol in relation to inflammation
title_fullStr Cold stimuli, hot topic: An updated review on the biological activity of menthol in relation to inflammation
title_full_unstemmed Cold stimuli, hot topic: An updated review on the biological activity of menthol in relation to inflammation
title_short Cold stimuli, hot topic: An updated review on the biological activity of menthol in relation to inflammation
title_sort cold stimuli hot topic an updated review on the biological activity of menthol in relation to inflammation
topic menthol
inflammation
review
TRPM-8
natural products
url https://www.frontiersin.org/articles/10.3389/fimmu.2022.1023746/full
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