Adaptation of prelimbic cortex mediated by IL-6/STAT3/Acp5 pathway contributes to the comorbidity of neuropathic pain and depression in rats

Adaptation of prelimbic cortex mediated by IL-6/STAT3/Acp5 pathway contributes to the comorbidity of neuropathic pain and depression in rats

Abstract Background The adaption of brain region is fundamental to the development and maintenance of nervous system disorders. The prelimbic cortex (PrL) participates in the affective components of the pain sensation. However, whether and how the adaptation of PrL contributes to the comorbidity of...

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Bibliographic Details
Main Authors: Yu-Ting Zhao, Jie Deng, He-Ming Liu, Jia-You Wei, Hai-Ting Fan, Meng Liu, Ting Xu, Ting-Feng Chen, Jing-Yi He, Wei-Ming Sun, Tao-Yu Jia, Xue-Qin Zhang, Wen-Jun Xin
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Neuroinflammation
Subjects:
Comorbid
Depression
Neuropathic pain
Spared nerve injury
Prelimbic cortex
IL-6
Online Access:https://doi.org/10.1186/s12974-022-02503-0

Internet

https://doi.org/10.1186/s12974-022-02503-0

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