CRISPR/dCas9-based metabolic pathway engineering for the systematic optimization of exopolysaccharide biosynthesis in Streptococcus thermophilus

CRISPR/dCas9-based metabolic pathway engineering for the systematic optimization of exopolysaccharide biosynthesis in Streptococcus thermophilus

ABSTRACT: Streptococcus thermophilus is used extensively in the dairy industry and has shown great promise as a chassis cell for the biosynthesis of high-value metabolites. However, metabolic engineering in S. thermophilus lacks effective genetic modification tools to modulate gene expression to rel...

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Autors principals: Linghui Kong, Zhiqiang Xiong, Xin Song, Yongjun Xia, Lianzhong Ai
Format: Article
Idioma:English
Publicat: Elsevier 2022-08-01
Col·lecció:Journal of Dairy Science
Matèries:
CRISPR interference
multiplex gene repression
exopolysaccharide biosynthesis
uridine diphosphate glucose sugar metabolism
Streptococcus thermophilus
Accés en línia:http://www.sciencedirect.com/science/article/pii/S002203022200337X

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http://www.sciencedirect.com/science/article/pii/S002203022200337X

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