Implications the Role of miR-155 in the Pathogenesis of Autoimmune Diseases
MicroRNAs (miRNAs) are small noncoding conserved RNAs containing 19 to 24 nucleotides that are regulators of post-translational modifications and are involved in the majority of biological processes such as immune homeostasis, T helper cell differentiation, central and peripheral tolerance, and immu...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2021-05-01
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Series: | Frontiers in Immunology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.669382/full |
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author | Salar Pashangzadeh Morteza Motallebnezhad Fatemeh Vafashoar Azadeh Khalvandi Nazanin Mojtabavi |
author_facet | Salar Pashangzadeh Morteza Motallebnezhad Fatemeh Vafashoar Azadeh Khalvandi Nazanin Mojtabavi |
author_sort | Salar Pashangzadeh |
collection | DOAJ |
description | MicroRNAs (miRNAs) are small noncoding conserved RNAs containing 19 to 24 nucleotides that are regulators of post-translational modifications and are involved in the majority of biological processes such as immune homeostasis, T helper cell differentiation, central and peripheral tolerance, and immune cell development. Autoimmune diseases are characterized by immune system dysregulation, which ultimately leads to destructive responses to self-antigens. A large body of literature suggests that autoimmune diseases and immune dysregulation are associated with different miRNA expression changes in the target cells and tissues of adaptive or innate immunity. miR-155 is identified as a critical modulator of immune responses. Recently conducted studies on the expression profile of miR-155 suggest that the altered expression and function of miR-155 can mediate vulnerability to autoimmune diseases and cause significant dysfunction of the immune system. |
first_indexed | 2024-12-17T07:36:49Z |
format | Article |
id | doaj.art-3c01adf3685d4d3a837ab8cb521abc60 |
institution | Directory Open Access Journal |
issn | 1664-3224 |
language | English |
last_indexed | 2024-12-17T07:36:49Z |
publishDate | 2021-05-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Immunology |
spelling | doaj.art-3c01adf3685d4d3a837ab8cb521abc602022-12-21T21:58:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-05-011210.3389/fimmu.2021.669382669382Implications the Role of miR-155 in the Pathogenesis of Autoimmune DiseasesSalar PashangzadehMorteza MotallebnezhadFatemeh VafashoarAzadeh KhalvandiNazanin MojtabaviMicroRNAs (miRNAs) are small noncoding conserved RNAs containing 19 to 24 nucleotides that are regulators of post-translational modifications and are involved in the majority of biological processes such as immune homeostasis, T helper cell differentiation, central and peripheral tolerance, and immune cell development. Autoimmune diseases are characterized by immune system dysregulation, which ultimately leads to destructive responses to self-antigens. A large body of literature suggests that autoimmune diseases and immune dysregulation are associated with different miRNA expression changes in the target cells and tissues of adaptive or innate immunity. miR-155 is identified as a critical modulator of immune responses. Recently conducted studies on the expression profile of miR-155 suggest that the altered expression and function of miR-155 can mediate vulnerability to autoimmune diseases and cause significant dysfunction of the immune system.https://www.frontiersin.org/articles/10.3389/fimmu.2021.669382/fullmiRNAmiR-155autoimmune diseaseimmune systemtolerance |
spellingShingle | Salar Pashangzadeh Morteza Motallebnezhad Fatemeh Vafashoar Azadeh Khalvandi Nazanin Mojtabavi Implications the Role of miR-155 in the Pathogenesis of Autoimmune Diseases Frontiers in Immunology miRNA miR-155 autoimmune disease immune system tolerance |
title | Implications the Role of miR-155 in the Pathogenesis of Autoimmune Diseases |
title_full | Implications the Role of miR-155 in the Pathogenesis of Autoimmune Diseases |
title_fullStr | Implications the Role of miR-155 in the Pathogenesis of Autoimmune Diseases |
title_full_unstemmed | Implications the Role of miR-155 in the Pathogenesis of Autoimmune Diseases |
title_short | Implications the Role of miR-155 in the Pathogenesis of Autoimmune Diseases |
title_sort | implications the role of mir 155 in the pathogenesis of autoimmune diseases |
topic | miRNA miR-155 autoimmune disease immune system tolerance |
url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.669382/full |
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