DJ-1 Proteoforms in Breast Cancer Cells: The Escape of Metabolic Epigenetic Misregulation

DJ-1 Proteoforms in Breast Cancer Cells: The Escape of Metabolic Epigenetic Misregulation

Enhanced glycolysis is a hallmark of breast cancer. In cancer cells, the high glycolytic flux induces carbonyl stress, a damaging condition in which the increase of reactive carbonyl species makes DNA, proteins, and lipids more susceptible to glycation. Together with glucose, methylglyoxal (MGO), a...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Domenica Scumaci, Erika Olivo, Claudia Vincenza Fiumara, Marina La Chimia, Maria Teresa De Angelis, Sabrina Mauro, Giosuè Costa, Francesca Alessandra Ambrosio, Stefano Alcaro, Valter Agosti, Francesco Saverio Costanzo, Giovanni Cuda
Format: Artikel
Sprache:English
Veröffentlicht: MDPI AG 2020-08-01
Schriftenreihe:Cells
Schlagworte:
metabolic rewiring
DJ-1
AGEs
Akt
breast cancer
histones
Online Zugang:https://www.mdpi.com/2073-4409/9/9/1968

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