DJ-1 Proteoforms in Breast Cancer Cells: The Escape of Metabolic Epigenetic Misregulation

DJ-1 Proteoforms in Breast Cancer Cells: The Escape of Metabolic Epigenetic Misregulation

Enhanced glycolysis is a hallmark of breast cancer. In cancer cells, the high glycolytic flux induces carbonyl stress, a damaging condition in which the increase of reactive carbonyl species makes DNA, proteins, and lipids more susceptible to glycation. Together with glucose, methylglyoxal (MGO), a...

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Détails bibliographiques
Auteurs principaux: Domenica Scumaci, Erika Olivo, Claudia Vincenza Fiumara, Marina La Chimia, Maria Teresa De Angelis, Sabrina Mauro, Giosuè Costa, Francesca Alessandra Ambrosio, Stefano Alcaro, Valter Agosti, Francesco Saverio Costanzo, Giovanni Cuda
Format: Article
Langue:English
Publié: MDPI AG 2020-08-01
Collection:Cells
Sujets:
metabolic rewiring
DJ-1
AGEs
Akt
breast cancer
histones
Accès en ligne:https://www.mdpi.com/2073-4409/9/9/1968

Internet

https://www.mdpi.com/2073-4409/9/9/1968

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