Multi-Omic, Histopathologic, and Clinicopathologic Effects of Once-Weekly Oral Rapamycin in a Naturally Occurring Feline Model of Hypertrophic Cardiomyopathy: A Pilot Study

Multi-Omic, Histopathologic, and Clinicopathologic Effects of Once-Weekly Oral Rapamycin in a Naturally Occurring Feline Model of Hypertrophic Cardiomyopathy: A Pilot Study

Hypertrophic cardiomyopathy (HCM) remains the single most common cardiomyopathy in cats, with a staggering prevalence as high as 15%. To date, little to no direct therapeutical intervention for HCM exists for veterinary patients. A previous study aimed to evaluate the effects of delayed-release (DR)...

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Bibliographic Details
Main Authors: Victor N. Rivas, Joanna L. Kaplan, Susan A. Kennedy, Stuart Fitzgerald, Amanda E. Crofton, Aisling Farrell, Louise Grubb, Carina E. Jauregui, Gabriela Grigorean, Eunju Choi, Samantha P. Harris, Joshua A. Stern
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Animals
Subjects:
mTOR (mammalian/mechanistic target of rapamycin)
transcriptomics (RNA sequencing)
proteomics (LCMS)
sirolimus
autophagy
cat
Online Access:https://www.mdpi.com/2076-2615/13/20/3184

Internet

https://www.mdpi.com/2076-2615/13/20/3184

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