Cilia in the choroid plexus: their roles in hydrocephalus and beyond
Cilia are whip-like projections that are widely conserved in eukaryotes and function as a motile propeller and/or sensory platform to detect various extracellular stimuli. In vertebrates, cilia are ubiquitously found in most cells, showing structural and functional diversities depending on the cell...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2015-02-01
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Series: | Frontiers in Cellular Neuroscience |
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00039/full |
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author | Keishi eNarita Sen eTakeda |
author_facet | Keishi eNarita Sen eTakeda |
author_sort | Keishi eNarita |
collection | DOAJ |
description | Cilia are whip-like projections that are widely conserved in eukaryotes and function as a motile propeller and/or sensory platform to detect various extracellular stimuli. In vertebrates, cilia are ubiquitously found in most cells, showing structural and functional diversities depending on the cell type. In this review, we focus on the structure and function of cilia in choroid plexus epithelial cells (CPECs). CPECs form one or two dozen non-motile 9+0 cilia, which display transient acquisition of motility during development. Genetic malfunction of cilia can lead to failure of multiple organs including the brain. Especially, several groups have demonstrated that the defects in CPEC cilia cause the communicating form of hydrocephalus. In order to elucidate the molecular mechanisms underlying the hydrocephalus, we have previously demonstrated that the cilia possess an NPFF receptor for autocrine signaling to regulate transepithelial fluid transport. In this perspective, we also discuss the potential involvement of cilia in the other aspects of choroid plexus functions, such as the regulation of brain development and neuroinflammation. |
first_indexed | 2024-12-11T09:51:06Z |
format | Article |
id | doaj.art-554d42cff6f744a3b9a79577151631da |
institution | Directory Open Access Journal |
issn | 1662-5102 |
language | English |
last_indexed | 2024-12-11T09:51:06Z |
publishDate | 2015-02-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Cellular Neuroscience |
spelling | doaj.art-554d42cff6f744a3b9a79577151631da2022-12-22T01:12:25ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-02-01910.3389/fncel.2015.00039120731Cilia in the choroid plexus: their roles in hydrocephalus and beyondKeishi eNarita0Sen eTakeda1University of YamanashiUniversity of YamanashiCilia are whip-like projections that are widely conserved in eukaryotes and function as a motile propeller and/or sensory platform to detect various extracellular stimuli. In vertebrates, cilia are ubiquitously found in most cells, showing structural and functional diversities depending on the cell type. In this review, we focus on the structure and function of cilia in choroid plexus epithelial cells (CPECs). CPECs form one or two dozen non-motile 9+0 cilia, which display transient acquisition of motility during development. Genetic malfunction of cilia can lead to failure of multiple organs including the brain. Especially, several groups have demonstrated that the defects in CPEC cilia cause the communicating form of hydrocephalus. In order to elucidate the molecular mechanisms underlying the hydrocephalus, we have previously demonstrated that the cilia possess an NPFF receptor for autocrine signaling to regulate transepithelial fluid transport. In this perspective, we also discuss the potential involvement of cilia in the other aspects of choroid plexus functions, such as the regulation of brain development and neuroinflammation.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00039/fullCerebrospinal FluidCiliaHydrocephalusdiversityMulticiliogenesis |
spellingShingle | Keishi eNarita Sen eTakeda Cilia in the choroid plexus: their roles in hydrocephalus and beyond Frontiers in Cellular Neuroscience Cerebrospinal Fluid Cilia Hydrocephalus diversity Multiciliogenesis |
title | Cilia in the choroid plexus: their roles in hydrocephalus and beyond |
title_full | Cilia in the choroid plexus: their roles in hydrocephalus and beyond |
title_fullStr | Cilia in the choroid plexus: their roles in hydrocephalus and beyond |
title_full_unstemmed | Cilia in the choroid plexus: their roles in hydrocephalus and beyond |
title_short | Cilia in the choroid plexus: their roles in hydrocephalus and beyond |
title_sort | cilia in the choroid plexus their roles in hydrocephalus and beyond |
topic | Cerebrospinal Fluid Cilia Hydrocephalus diversity Multiciliogenesis |
url | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00039/full |
work_keys_str_mv | AT keishienarita ciliainthechoroidplexustheirrolesinhydrocephalusandbeyond AT senetakeda ciliainthechoroidplexustheirrolesinhydrocephalusandbeyond |