Cilia in the choroid plexus: their roles in hydrocephalus and beyond

Cilia are whip-like projections that are widely conserved in eukaryotes and function as a motile propeller and/or sensory platform to detect various extracellular stimuli. In vertebrates, cilia are ubiquitously found in most cells, showing structural and functional diversities depending on the cell...

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Main Authors: Keishi eNarita, Sen eTakeda
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00039/full
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author Keishi eNarita
Sen eTakeda
author_facet Keishi eNarita
Sen eTakeda
author_sort Keishi eNarita
collection DOAJ
description Cilia are whip-like projections that are widely conserved in eukaryotes and function as a motile propeller and/or sensory platform to detect various extracellular stimuli. In vertebrates, cilia are ubiquitously found in most cells, showing structural and functional diversities depending on the cell type. In this review, we focus on the structure and function of cilia in choroid plexus epithelial cells (CPECs). CPECs form one or two dozen non-motile 9+0 cilia, which display transient acquisition of motility during development. Genetic malfunction of cilia can lead to failure of multiple organs including the brain. Especially, several groups have demonstrated that the defects in CPEC cilia cause the communicating form of hydrocephalus. In order to elucidate the molecular mechanisms underlying the hydrocephalus, we have previously demonstrated that the cilia possess an NPFF receptor for autocrine signaling to regulate transepithelial fluid transport. In this perspective, we also discuss the potential involvement of cilia in the other aspects of choroid plexus functions, such as the regulation of brain development and neuroinflammation.
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spelling doaj.art-554d42cff6f744a3b9a79577151631da2022-12-22T01:12:25ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-02-01910.3389/fncel.2015.00039120731Cilia in the choroid plexus: their roles in hydrocephalus and beyondKeishi eNarita0Sen eTakeda1University of YamanashiUniversity of YamanashiCilia are whip-like projections that are widely conserved in eukaryotes and function as a motile propeller and/or sensory platform to detect various extracellular stimuli. In vertebrates, cilia are ubiquitously found in most cells, showing structural and functional diversities depending on the cell type. In this review, we focus on the structure and function of cilia in choroid plexus epithelial cells (CPECs). CPECs form one or two dozen non-motile 9+0 cilia, which display transient acquisition of motility during development. Genetic malfunction of cilia can lead to failure of multiple organs including the brain. Especially, several groups have demonstrated that the defects in CPEC cilia cause the communicating form of hydrocephalus. In order to elucidate the molecular mechanisms underlying the hydrocephalus, we have previously demonstrated that the cilia possess an NPFF receptor for autocrine signaling to regulate transepithelial fluid transport. In this perspective, we also discuss the potential involvement of cilia in the other aspects of choroid plexus functions, such as the regulation of brain development and neuroinflammation.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00039/fullCerebrospinal FluidCiliaHydrocephalusdiversityMulticiliogenesis
spellingShingle Keishi eNarita
Sen eTakeda
Cilia in the choroid plexus: their roles in hydrocephalus and beyond
Frontiers in Cellular Neuroscience
Cerebrospinal Fluid
Cilia
Hydrocephalus
diversity
Multiciliogenesis
title Cilia in the choroid plexus: their roles in hydrocephalus and beyond
title_full Cilia in the choroid plexus: their roles in hydrocephalus and beyond
title_fullStr Cilia in the choroid plexus: their roles in hydrocephalus and beyond
title_full_unstemmed Cilia in the choroid plexus: their roles in hydrocephalus and beyond
title_short Cilia in the choroid plexus: their roles in hydrocephalus and beyond
title_sort cilia in the choroid plexus their roles in hydrocephalus and beyond
topic Cerebrospinal Fluid
Cilia
Hydrocephalus
diversity
Multiciliogenesis
url http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00039/full
work_keys_str_mv AT keishienarita ciliainthechoroidplexustheirrolesinhydrocephalusandbeyond
AT senetakeda ciliainthechoroidplexustheirrolesinhydrocephalusandbeyond