Conditional RNA interference in mammalian cells via RNA transactivation

Abstract RNA interference (RNAi) is a powerful tool for sequence-specific gene knockdown in therapeutic and research applications. However, spatiotemporal control of RNAi is required to decrease nonspecific targeting, potential toxicity, and allow targeting of essential genes. Herein we describe a c...

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Détails bibliographiques
Auteurs principaux: Yu Zhou, Peike Sheng, Jiayi Li, Yudan Li, Mingyi Xie, Alexander A. Green
Format: Article
Langue:English
Publié: Nature Portfolio 2024-08-01
Collection:Nature Communications
Accès en ligne:https://doi.org/10.1038/s41467-024-50600-w