Caliciviral protein-based artificial translational activator for mammalian gene circuits with RNA-only delivery

Synthetic RNA-based circuits allow for gene regulation without the risk of mutagenesis. Here the authors demonstrate a Caliciviral VPg-based Translational activator which allows translational activation of synthetic mRNAs.

Bibliographic Details
Main Authors: Hideyuki Nakanishi, Hirohide Saito
Format: Article
Language:English
Published: Nature Portfolio 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15061-x