Nucleos(t)ide analogues potentially activate T lymphocytes through inducing interferon expression in hepatic cells and patients with chronic hepatitis B

Nucleos(t)ide analogues potentially activate T lymphocytes through inducing interferon expression in hepatic cells and patients with chronic hepatitis B

Abstract Chronic hepatitis B (CHB) leads to liver inflammation and dysfunction, resulting in liver fibrosis and cancer. Nucleos(t)ide analogues (NAs), inhibitors of hepatitis B virus (HBV), specifically suppress HBV replication. We proposed that immune modulation benefits seroconversion by HBsAg los...

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Bibliographic Details
Main Authors: Ai-Sheng Ho, Jungshan Chang, Shou-Dong Lee, Zong-Lin Sie, Hui-Fen Shih, Chun Yeh, Cheng-Liang Peng, Kapil Dev, Chun-Chia Cheng
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
CD4+ T cells
CD8+ T cells
HBV
Nucleoside/nucleotide analogues (NAs)
IFN
PD-L1
Online Access:https://doi.org/10.1038/s41598-024-76270-8

Internet

https://doi.org/10.1038/s41598-024-76270-8

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