Chemometric technique for the optimization of chromatographic system: Simultaneous HPLC determination of Rosuvastatin, Telmisartan, Ezetimibe and Atorvastatin used in combined cardiovascular therapy

Chemometric technique for the optimization of chromatographic system: Simultaneous HPLC determination of Rosuvastatin, Telmisartan, Ezetimibe and Atorvastatin used in combined cardiovascular therapy

Developed and optimized a validated isocratic reverse phase HPLC separation of Rosuvastatin, Telmisartan, Ezetimibe and Atorvastatin in pharmaceutical preparation using response surface methodology. The separation was carried out by using phenomenex C18 column (15 cm × 4.6 mm id, 5 μm particle size)...

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Detalhes bibliográficos
Principais autores: V. Sree Janardhanan, R. Manavalan, K. Valliappan
Formato: Artigo
Idioma:English
Publicado em: Elsevier 2016-11-01
coleção:Arabian Journal of Chemistry
Assuntos:
Atorvastatin
Central composite design
Derringer's desirability function
Ezetimibe
Rosuvastatin
Telmisartan
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1878535212000470

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http://www.sciencedirect.com/science/article/pii/S1878535212000470

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