Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module

Combined the home made PET-MV-2-IT module with carbon-11 methyl iodide module, it was used for synthesis of carbon-11 radiotracers. Methylation agent 11C-CH3-Triflate was synthesized with methyl iodide module. The11C-CH3-Triflate was bubbled to the second reaction vessels in PET-MV-2-IT module,...

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Main Author: ZHANG Jin-ming;ZHANG Xiao-jun;LIU Jian;CHEN Ying-mao;TIAN Jia-he
Format: Article
Language:zho
Published: Editorial Board of Journal of Isotopes 2014-02-01
Series:Journal of Isotopes
Subjects:
Online Access:http://www.tws.org.cn/CN/10.7538/tws.2014.27.01.0028
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author ZHANG Jin-ming;ZHANG Xiao-jun;LIU Jian;CHEN Ying-mao;TIAN Jia-he
author_facet ZHANG Jin-ming;ZHANG Xiao-jun;LIU Jian;CHEN Ying-mao;TIAN Jia-he
author_sort ZHANG Jin-ming;ZHANG Xiao-jun;LIU Jian;CHEN Ying-mao;TIAN Jia-he
collection DOAJ
description Combined the home made PET-MV-2-IT module with carbon-11 methyl iodide module, it was used for synthesis of carbon-11 radiotracers. Methylation agent 11C-CH3-Triflate was synthesized with methyl iodide module. The11C-CH3-Triflate was bubbled to the second reaction vessels in PET-MV-2-IT module, which the precursors were stored. The productions were purified by semi-HPLC and solid phase extraction (SPE) to get the final radiopharmaceuticals. There are four carbon-11 radiopharmaceuticals were synthesized with the method, which it were 11C-Raclopride,11C-PIB,11C-DASB and 11C-PK11195,and synthesis yields were (38.2±4.5)% (n=10),(68.4±3.2)% (n=12), (52.4±5.5)%(n=4)and (45.6±7.1)% (n=8)respectively. All productions radiochemical purity were over 95%. Assembled the methyl iodide module with PET-MV-2-F, which it had semi-HPLC, we can synthesize most carbon-11 radiopharmaceuticals for clinical used.
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spelling doaj.art-7d93665a8b4143d581f82cdb8d5317072022-12-21T21:49:43ZzhoEditorial Board of Journal of IsotopesJournal of Isotopes1000-75121000-75122014-02-01271283410.7538/tws.2014.27.01.0028 Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide ModuleZHANG Jin-ming;ZHANG Xiao-jun;LIU Jian;CHEN Ying-mao;TIAN Jia-heCombined the home made PET-MV-2-IT module with carbon-11 methyl iodide module, it was used for synthesis of carbon-11 radiotracers. Methylation agent 11C-CH3-Triflate was synthesized with methyl iodide module. The11C-CH3-Triflate was bubbled to the second reaction vessels in PET-MV-2-IT module, which the precursors were stored. The productions were purified by semi-HPLC and solid phase extraction (SPE) to get the final radiopharmaceuticals. There are four carbon-11 radiopharmaceuticals were synthesized with the method, which it were 11C-Raclopride,11C-PIB,11C-DASB and 11C-PK11195,and synthesis yields were (38.2±4.5)% (n=10),(68.4±3.2)% (n=12), (52.4±5.5)%(n=4)and (45.6±7.1)% (n=8)respectively. All productions radiochemical purity were over 95%. Assembled the methyl iodide module with PET-MV-2-F, which it had semi-HPLC, we can synthesize most carbon-11 radiopharmaceuticals for clinical used.http://www.tws.org.cn/CN/10.7538/tws.2014.27.01.0028 synthesis fluorine-18 carbon-11 auto-synthesis module radiopharmaceuticals
spellingShingle ZHANG Jin-ming;ZHANG Xiao-jun;LIU Jian;CHEN Ying-mao;TIAN Jia-he
Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module
Journal of Isotopes
synthesis fluorine-18 carbon-11 auto-synthesis module radiopharmaceuticals
title Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module
title_full Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module
title_fullStr Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module
title_full_unstemmed Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module
title_short Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module
title_sort fully automated synthesis carbon 11 radiopharmaceuticals using home made pet mv 2 f module assembled the methyl iodide module
topic synthesis fluorine-18 carbon-11 auto-synthesis module radiopharmaceuticals
url http://www.tws.org.cn/CN/10.7538/tws.2014.27.01.0028
work_keys_str_mv AT zhangjinmingzhangxiaojunliujianchenyingmaotianjiahe fullyautomatedsynthesiscarbon11radiopharmaceuticalsusinghomemadepetmv2fmoduleassembledthemethyliodidemodule