Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module
Combined the home made PET-MV-2-IT module with carbon-11 methyl iodide module, it was used for synthesis of carbon-11 radiotracers. Methylation agent 11C-CH3-Triflate was synthesized with methyl iodide module. The11C-CH3-Triflate was bubbled to the second reaction vessels in PET-MV-2-IT module,...
Main Author: | |
---|---|
Format: | Article |
Language: | zho |
Published: |
Editorial Board of Journal of Isotopes
2014-02-01
|
Series: | Journal of Isotopes |
Subjects: | |
Online Access: | http://www.tws.org.cn/CN/10.7538/tws.2014.27.01.0028 |
_version_ | 1818689066116317184 |
---|---|
author | ZHANG Jin-ming;ZHANG Xiao-jun;LIU Jian;CHEN Ying-mao;TIAN Jia-he |
author_facet | ZHANG Jin-ming;ZHANG Xiao-jun;LIU Jian;CHEN Ying-mao;TIAN Jia-he |
author_sort | ZHANG Jin-ming;ZHANG Xiao-jun;LIU Jian;CHEN Ying-mao;TIAN Jia-he |
collection | DOAJ |
description | Combined the home made PET-MV-2-IT module with carbon-11 methyl iodide module, it was used for synthesis of carbon-11 radiotracers. Methylation agent 11C-CH3-Triflate was synthesized with methyl iodide module. The11C-CH3-Triflate was bubbled to the second reaction vessels in PET-MV-2-IT module, which the precursors were stored. The productions were purified by semi-HPLC and solid phase extraction (SPE) to get the final radiopharmaceuticals. There are four carbon-11 radiopharmaceuticals were synthesized with the method, which it were 11C-Raclopride,11C-PIB,11C-DASB and 11C-PK11195,and synthesis yields were (38.2±4.5)% (n=10),(68.4±3.2)% (n=12), (52.4±5.5)%(n=4)and (45.6±7.1)% (n=8)respectively. All productions radiochemical purity were over 95%. Assembled the methyl iodide module with PET-MV-2-F, which it had semi-HPLC, we can synthesize most carbon-11 radiopharmaceuticals for clinical used. |
first_indexed | 2024-12-17T12:04:11Z |
format | Article |
id | doaj.art-7d93665a8b4143d581f82cdb8d531707 |
institution | Directory Open Access Journal |
issn | 1000-7512 1000-7512 |
language | zho |
last_indexed | 2024-12-17T12:04:11Z |
publishDate | 2014-02-01 |
publisher | Editorial Board of Journal of Isotopes |
record_format | Article |
series | Journal of Isotopes |
spelling | doaj.art-7d93665a8b4143d581f82cdb8d5317072022-12-21T21:49:43ZzhoEditorial Board of Journal of IsotopesJournal of Isotopes1000-75121000-75122014-02-01271283410.7538/tws.2014.27.01.0028 Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide ModuleZHANG Jin-ming;ZHANG Xiao-jun;LIU Jian;CHEN Ying-mao;TIAN Jia-heCombined the home made PET-MV-2-IT module with carbon-11 methyl iodide module, it was used for synthesis of carbon-11 radiotracers. Methylation agent 11C-CH3-Triflate was synthesized with methyl iodide module. The11C-CH3-Triflate was bubbled to the second reaction vessels in PET-MV-2-IT module, which the precursors were stored. The productions were purified by semi-HPLC and solid phase extraction (SPE) to get the final radiopharmaceuticals. There are four carbon-11 radiopharmaceuticals were synthesized with the method, which it were 11C-Raclopride,11C-PIB,11C-DASB and 11C-PK11195,and synthesis yields were (38.2±4.5)% (n=10),(68.4±3.2)% (n=12), (52.4±5.5)%(n=4)and (45.6±7.1)% (n=8)respectively. All productions radiochemical purity were over 95%. Assembled the methyl iodide module with PET-MV-2-F, which it had semi-HPLC, we can synthesize most carbon-11 radiopharmaceuticals for clinical used.http://www.tws.org.cn/CN/10.7538/tws.2014.27.01.0028 synthesis fluorine-18 carbon-11 auto-synthesis module radiopharmaceuticals |
spellingShingle | ZHANG Jin-ming;ZHANG Xiao-jun;LIU Jian;CHEN Ying-mao;TIAN Jia-he Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module Journal of Isotopes synthesis fluorine-18 carbon-11 auto-synthesis module radiopharmaceuticals |
title | Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module |
title_full | Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module |
title_fullStr | Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module |
title_full_unstemmed | Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module |
title_short | Fully Automated Synthesis Carbon-11 Radiopharmaceuticals using Home Made PET-MV-2-F Module Assembled the Methyl Iodide Module |
title_sort | fully automated synthesis carbon 11 radiopharmaceuticals using home made pet mv 2 f module assembled the methyl iodide module |
topic | synthesis fluorine-18 carbon-11 auto-synthesis module radiopharmaceuticals |
url | http://www.tws.org.cn/CN/10.7538/tws.2014.27.01.0028 |
work_keys_str_mv | AT zhangjinmingzhangxiaojunliujianchenyingmaotianjiahe fullyautomatedsynthesiscarbon11radiopharmaceuticalsusinghomemadepetmv2fmoduleassembledthemethyliodidemodule |