OGT mediated HDAC5 O-GlcNAcylation promotes osteogenesis by regulating the homeostasis of epigenetic modifications and proteolysis

OGT mediated HDAC5 O-GlcNAcylation promotes osteogenesis by regulating the homeostasis of epigenetic modifications and proteolysis

Background: O-GlcNAc transferase (OGT) is responsible for attaching O-linked N-acetylglucosamine (O-GlcNAc) to proteins, regulating diverse cellular processes ranging from transcription and translation to signaling and metabolism. This study focuses on the role and mechanisms of OGT in osteogenesis....

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Bibliographic Details
Main Authors: Yu Du, Xiang Gao, Jianqiang Chen, Xinxin Chen, Hang Liu, Wenge He, Lu Liu, Yue Jiang, Baicheng He, Zhongliang Deng, Chao Liang, Fengjin Guo
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Journal of Orthopaedic Translation
Subjects:
HDAC5
O-GlcNAcylation
OGT
Osteogenesis
Proteolysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X24001347

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http://www.sciencedirect.com/science/article/pii/S2214031X24001347

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