Impact of Hydrophobic, Hydrophilic, and Mucus-Binding Motifs on the Therapeutic Potential of Ceftazidime Analogs for Pulmonary Administration

Impact of Hydrophobic, Hydrophilic, and Mucus-Binding Motifs on the Therapeutic Potential of Ceftazidime Analogs for Pulmonary Administration

<b>Background/Objectives</b>: The pulmonary administration of antibiotics can be advantageous in treating pulmonary infections by promoting high intrapulmonary drug concentrations with reduced systemic exposure. However, limited benefits have been observed for pulmonary administration ve...

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Bibliographic Details
Main Authors: Kyle D. Apley, Stephanie N. Johnson, Jian Qian, Indeewara Munasinghe, Jennifer R. Klaus, Srilaxmi M. Patel, Kathryn E. Woods, Samalee Banerjee, Josephine R. Chandler, Chamani Perera, Nathalie Baumlin, Matthias Salathe, Cory J. Berkland
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Antibiotics
Subjects:
antibacterial(s)
drug design
drug transport
epithelial permeability
pulmonary drug delivery
Online Access:https://www.mdpi.com/2079-6382/14/2/177

Internet

https://www.mdpi.com/2079-6382/14/2/177

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