A novel approach toward the multigram synthesis of a novel Bcl2-specific inhibitor, and evaluation of its biological activity

A novel approach toward the multigram synthesis of a novel Bcl2-specific inhibitor, and evaluation of its biological activity

The antiapoptotic protein BCL2 is overexpressed in several cancers. It contributes to prolonged cell survival and chemoresistance, making it an excellent target for targeted cancer therapy. Over the years, several BCL2 inhibitors have been investigated extensively for their anticancer potential; how...

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Bibliographic Details
Main Authors: Manthra Raveendran, Shivangi Sharma, Sanjay Sambhajirao Palimkar, M. Lakshmana Kumar, H. Sahana, Hassan A. Swarup, Sathees C. Raghavan
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
BCL2 inhibitor
Apoptosis
Cancer therapy
imidazo[2,1-b][1,3,4]thiadiazole-linked oxindole
Domino reaction
Targeted therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417424000293

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http://www.sciencedirect.com/science/article/pii/S2772417424000293

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