Indolo‐pyrido‐isoquinolin based alkaloid inhibits growth, invasion and migration of breast cancer cells via activation of p53‐miR34a axis

Indolo‐pyrido‐isoquinolin based alkaloid inhibits growth, invasion and migration of breast cancer cells via activation of p53‐miR34a axis

The tumor suppressor p53 plays a critical role in suppressing cancer growth and progression and is an attractive target for the development of new targeted therapies. We synthesized several indolo‐pyrido‐isoquinolin based alkaloids to activate p53 function and examined their therapeutic efficacy usi...

Full description

Bibliographic Details
Main Authors: Dimiter B. Avtanski, Arumugam Nagalingam, Joseph E. Tomaszewski, Prabhakar Risbood, Michael J. Difillippantonio, Neeraj K. Saxena, Sanjay V. Malhotra, Dipali Sharma
Format: Article
Language:English
Published: Wiley 2016-08-01
Series:Molecular Oncology
Subjects:
p53
miR34a
Indolo‐pyrido‐isoquinolin based alkaloid
Breast cancer
EMT
Invasion
Online Access:https://doi.org/10.1016/j.molonc.2016.04.003

Internet

https://doi.org/10.1016/j.molonc.2016.04.003

Similar Items