Indolo‐pyrido‐isoquinolin based alkaloid inhibits growth, invasion and migration of breast cancer cells via activation of p53‐miR34a axis

Indolo‐pyrido‐isoquinolin based alkaloid inhibits growth, invasion and migration of breast cancer cells via activation of p53‐miR34a axis

The tumor suppressor p53 plays a critical role in suppressing cancer growth and progression and is an attractive target for the development of new targeted therapies. We synthesized several indolo‐pyrido‐isoquinolin based alkaloids to activate p53 function and examined their therapeutic efficacy usi...

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Manylion Llyfryddiaeth
Prif Awduron: Dimiter B. Avtanski, Arumugam Nagalingam, Joseph E. Tomaszewski, Prabhakar Risbood, Michael J. Difillippantonio, Neeraj K. Saxena, Sanjay V. Malhotra, Dipali Sharma
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Wiley 2016-08-01
Cyfres:Molecular Oncology
Pynciau:
p53
miR34a
Indolo‐pyrido‐isoquinolin based alkaloid
Breast cancer
EMT
Invasion
Mynediad Ar-lein:https://doi.org/10.1016/j.molonc.2016.04.003

Rhyngrwyd

https://doi.org/10.1016/j.molonc.2016.04.003

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